公开(公告)号：US20230028441A1

公开(公告)日：2023-01-26

申请号：US17767018

申请日：2020-10-08

Applicant: Bayer Aktiengesellschaft

Inventor： Peter JESCHKE ,  Hans-Georg SCHWARZ ,  Alexander ARLT ,  Martin FUESSLEIN ,  Yolanda CANCHO GRANDE ,  Joachim TELSER ,  Peter LOESEL ,  Marc LINKA ,  Ulrich EBBINGHAUS-KINTSCHER ,  Arunas Jonas DAMIJONAITIS ,  Elke HELLWEGE ,  Andreas TURBERG ,  Iring HEISLER

IPC: C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D417/04

Abstract: The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

公开(公告)号：US20230027985A1

公开(公告)日：2023-01-26

申请号：US17776961

申请日：2020-11-12

Applicant: Bayer Aktiengesellschaft ,  The Broad Institute, Inc.

Inventor： Daniel MEIBOM ,  Yolanda CANCHO GRANDE ,  Pierre WASNAIRE ,  Sarah Anna Liesa JOHANNES ,  Niels LINDNER ,  Kristin BEYER ,  Till FREUDENBERGER ,  Damian BROCKSCHNIEDER ,  Ilka MATHAR ,  Jürgen KLAR ,  Dmitry ZUBOV ,  Dzianis MENSHYKAU ,  Tanja KRAINZ ,  Eric STEFAN ,  Bryan MACDONALD ,  Yi XING ,  Nadine ELOWE ,  Guzman SANCHEZ

IPC: C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D401/14 ,  C07D403/12 ,  A61K45/06

Abstract: The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.

公开(公告)号：US20210155608A1

公开(公告)日：2021-05-27

申请号：US17047027

申请日：2019-04-15

Applicant: Bayer Aktiengesellschaft

Inventor： Alexander ARLT ,  Werner HALLENBACH ,  Hans-Georg SCHWARZ ,  Martin FUESSLEIN ,  Heinz-Juergen WROBLOWSKY ,  Marc LINKA ,  Ulrich GOERGENS ,  Kerstin ILG ,  Ulrich EBBINGHAUS-KINTSCHER ,  Yolanda CANCHO GRANDE ,  Arunas Jonas DAMIJONAITIS ,  Sascha EILMUS ,  Andreas TURBERG ,  Iring HEISLER

IPC: C07D403/04 ,  C07D405/14 ,  C07D403/14 ,  C07D401/14 ,  C07D409/14 ,  C07D401/04 ,  A01N43/653

Abstract: The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

公开(公告)号：US20240417391A1

公开(公告)日：2024-12-19

申请号：US18818025

申请日：2024-08-28

Applicant: Bayer Aktiengesellschaft

Inventor： Alexander ARLT ,  Werner HALLENBACH ,  Hans-Georg SCHWARZ ,  Martin FUESSLEIN ,  Heinz-Juergen WROBLOWSKY ,  Marc LINKA ,  Ulrich GOERGENS ,  Kerstin ILG ,  Ulrich EBBINGHAUS-KINTSCHER ,  Yolanda CANCHO GRANDE ,  Arunas Jonas DAMIJONAITIS ,  Sascha EILMUS ,  Andreas TURBERG ,  Iring HEISLER

IPC: C07D403/04 ,  A01N43/653 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

Abstract: The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

公开(公告)号：US20240368125A1

公开(公告)日：2024-11-07

申请号：US18685717

申请日：2022-08-19

Applicant: Bayer Aktiengesellschaft

Inventor： Robin Maximilian BAER ,  Yolanda CANCHO GRANDE ,  Martin FÙßLEIN ,  Peter JESCHKE ,  Hans-Georg SCHWARZ ,  Joachim TELSER ,  Philipp WINTER ,  Ulrich EBBINGHAUS-KINTSCHER ,  Peter LOESEL ,  Marc LINKA ,  Arunas DAMIJONAITIS ,  Andreas TURBERG ,  Iring HEISLER

IPC: C07D403/04 ,  A01N43/653 ,  A01P7/04

Abstract: The present invention relates to novel pyrazinyl-triazole compounds of the general formula (I), in which the structural elements X, R1, R2, R31, R31 and R4 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

公开(公告)号：US20230389550A1

公开(公告)日：2023-12-07

申请号：US18448395

申请日：2023-08-11

Applicant: BAYER AKTIENGESELLSCHAFT

Inventor： Alexander ARLT ,  Werner HALLENBACH ,  Hans-Georg SCHWARZ ,  Martin FUESSLEIN ,  Heinz-Juergen WROBLOWSKY ,  Estella BUSCATO ARSEQUELL ,  Marc LINKA ,  Kerstin ILG ,  Arunas Jonas DAMIJONAITIS ,  Ulrich EBBINGHAUS-KINTSCHER ,  Ulrich GOERGENS ,  Yolanda CANCHO GRANDE ,  Peter JESCHKE ,  Joachim TELSER ,  Iring HEISLER ,  Andreas TURBERG

IPC: A01N43/653 ,  A01P7/04 ,  A01N43/82 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04

CPC classification number: A01N43/653 ,  A01P7/04 ,  A01N43/82 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04

Abstract: The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

公开(公告)号：US20230348432A1

公开(公告)日：2023-11-02

申请号：US17997884

申请日：2021-05-05

Applicant: Bayer Aktiengesellschaft

Inventor： Peter JESCHKE ,  Martin FUESSLEIN ,  Hans-Georg SCHWARZ ,  Joachim TELSER ,  Yolanda CANCHO GRANDE ,  Alexander ARLT ,  Steffen MUELLER ,  Ulrich EBBINGHAUS-KINTSCHER ,  Peter LOESEL ,  Marc LINKA ,  Arunas Jonas DAMIJONAITIS ,  Iring HEISLER ,  Andreas TURBERG ,  Oleksandr MANDZHULO

IPC: C07D403/04 ,  A01N43/707 ,  C07D401/14 ,  A01P7/02 ,  A01P7/04 ,  A01P5/00

CPC classification number: C07D403/04 ,  A01N43/707 ,  C07D401/14 ,  A01P7/02 ,  A01P7/04 ,  A01P5/00

Abstract: The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, R1, R2, R3 and R4 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

公开(公告)号：US20230027346A1

公开(公告)日：2023-01-26

申请号：US17776987

申请日：2020-11-12

Applicant: BAYER AKTIENGESELLSCHAFT ,  THE BROAD INSTITUTE, INC.

Inventor： Daniel MEIBOM ,  Yolanda CANCHO GRANDE ,  Pierre WASNAIRE ,  Sarah Anna Liesa JOHANNES ,  Kristin BEYER ,  Till FREUDENBERGER ,  Damian BROCKSCHNIEDER ,  Dmitry ZUBOV ,  Dzianis MENSHYKAU ,  Tanja KRAINZ ,  Bryan MACDONALD ,  Yi XING ,  Nadine ELOWE ,  Guzman SANCHEZ

IPC: C07D403/04 ,  C07D417/04 ,  C07D233/02 ,  C07D401/12 ,  C07D405/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  A61P9/00 ,  A61K31/427 ,  A61K31/4178 ,  A61K31/4174 ,  A61K31/4166 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/4245 ,  A61K31/501 ,  A61K31/433

Abstract: The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; R2 is hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R3, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R2, R3, R4 is H; X1, X2, X3, X4, X5 and X6 are independently N or C; with the proviso that in each ring maximal one X is N.

公开(公告)号：US20220264880A1

公开(公告)日：2022-08-25

申请号：US17628519

申请日：2020-07-17

Applicant: Bayer Aktiengesellschaft

Inventor： Alexander ARLT ,  Hans-Georg SCHWARZ ,  Yolanda CANCHO GRANDE ,  Martin FUESSLEIN ,  Peter JESCHKE ,  Ulrich EBBINGHAUS-KINTSCHER ,  Marc LINKA ,  Peter LOESEL ,  Arunas Jonas DAMIJONAITIS ,  Andreas TURBERG ,  Iring HEISLER ,  Oleksandr MANDZHULO

IPC: A01N43/653 ,  C07D401/04 ,  C07D403/04 ,  C07D409/14 ,  C07D403/14 ,  A01N25/30 ,  A01N43/54

Abstract: The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

公开(公告)号：US20200016159A1

公开(公告)日：2020-01-16

申请号：US16335282

申请日：2017-09-18

Applicant: Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

Inventor： Michael HAERTER ,  Dirk KOSEMUND ,  Yolanda CANCHO GRANDE ,  Martina DELBECK ,  Bernd KALTHOF ,  Klemens LUSTIG ,  Frank SUESSMEIER

IPC: A61K31/519 ,  A61K9/20 ,  A61K9/00 ,  A61K9/08 ,  C07D495/04

Abstract: The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives having cyclic substituents in the 3 position, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.