公开(公告)号：US20170100237A1

公开(公告)日：2017-04-13

申请号：US15272747

申请日：2016-09-22

Applicant: Boston Scientific SciMed, Inc.

Inventor： Crystal Marie Anderson-Cunanan ,  Katherine Cora Fazackerley ,  Michael Eppihimer ,  Shannon Smith Kenwood ,  Natalia P. Sushkova ,  Karen Suzanne Lavery

IPC: A61F2/24 ,  A61L27/36 ,  C12N5/077 ,  A61L27/38

CPC classification number: A61F2/2415 ,  A61F2/2412 ,  A61F2/2418 ,  A61L27/3687 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3873 ,  A61L27/3886 ,  A61L27/3895 ,  A61L27/507 ,  A61L2430/20 ,  C12M21/08 ,  C12N5/0656 ,  C12N5/0661 ,  C12N2502/1347 ,  C12N2527/00 ,  C12N2537/10

Abstract: A prosthetic heart valve provided herein can include a cultured cell tissue leaflet. In some cases, a prosthetic heart valve can include a plurality of leaflets secured together and retained within the expandable tubular member. The cultured cell tissue can be obtained by culturing fibroblast cells, smooth muscle cells, or a combination thereof to form a sheet of cultured cells and chemically cross-linking the fibroblast cells while under tension. In some cases, the cultured cell tissue can be radially tensioned. In some cases, the cultured cell tissue can be bi-axially tensioned.

公开(公告)号：US20170000610A1

公开(公告)日：2017-01-05

申请号：US15193794

申请日：2016-06-27

Applicant: Boston Scientific SciMed, Inc.

Inventor： Michael Eppihimer ,  Peter G. Edelman

IPC: A61F2/24

Abstract: A prosthetic heart leaflet includes a fiber-reinforced structure including a plurality of composite fibers. Each composite fiber includes a core fiber and a sheathing fiber disposed about the core fiber, wherein the core fiber or the sheathing fiber has a curvilinear shape.

Abstract translation: 假体心脏小叶包括包括多个复合纤维的纤维增强结构。 每个复合纤维包括芯纤维和围绕芯纤维布置的护套纤维，其中芯纤维或护套纤维具有曲线形状。