公开(公告)号：US20240254110A1

公开(公告)日：2024-08-01

申请号：US18461253

申请日：2023-09-05

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Keith Jones ,  Carl Rye ,  Nicola Chessum ,  Matthew D. Cheeseman ,  Adele E. Pasqua ,  Kurt G. Pike ,  Paul F. Faulder

IPC: C07D405/12 ,  C07D319/18 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/08 ,  C07D491/056

CPC classification number: C07D405/12 ,  C07D319/18 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/08 ,  C07D491/056

Abstract: The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

公开(公告)号：US11124501B2

公开(公告)日：2021-09-21

申请号：US16212455

申请日：2018-12-06

Applicant: Cancer Research Technology Limited

Inventor： Keith Jones ,  Carl Rye ,  Nicola Chessum ,  Matthew Cheeseman ,  Adele E. Pasqua ,  Kurt G. Pike ,  Paul F. Faulder

IPC: C07D405/12 ,  C07D405/14 ,  C07D319/18 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/08 ,  C07D491/056 ,  A61K31/357 ,  A61K31/404 ,  A61K31/428 ,  A61K31/436 ,  A61P35/00

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

公开(公告)号：US09701664B2

公开(公告)日：2017-07-11

申请号：US15026911

申请日：2014-10-03

Applicant: Cancer Research Technology Limited

Inventor： Keith Jones ,  Carl Rye ,  Nicola Chessum ,  Matthew Cheeseman ,  Adele E. Pasqua ,  Kurt G. Pike ,  Paul F. Faulder

IPC: C07D405/12 ,  C07D405/14 ,  C07D319/18 ,  C07D407/12 ,  C07D471/04 ,  C07D491/056 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08

CPC classification number: C07D405/12 ,  C07D319/18 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/08 ,  C07D491/056

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.