公开(公告)号：US20240092790A1

公开(公告)日：2024-03-21

申请号：US18267177

申请日：2021-12-13

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Daniele PALA ,  Christine EDWARDS ,  Adele Elisa PASQUA ,  Prashant Bhimrao KAPADNIS ,  Arnaud Jean Francois Auguste CHEGUILLAUME ,  David Edward CLARK

IPC: C07D491/048

CPC classification number: C07D491/048

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20230092892A1

公开(公告)日：2023-03-23

申请号：US17615056

申请日：2020-05-28

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Paolo BRUNO ,  Matteo BIAGETTI ,  Claudio FIORELLI ,  Daniela PIZZIRANI ,  Daniele PALA ,  Paolo RONCHI ,  Charles BAKER-GLENN ,  Hervè VAN DE POËL ,  Kim Louise HIRST

IPC: C07D403/12 ,  C07D401/12 ,  C07D487/04 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D413/12 ,  C07D239/94 ,  C07D409/14 ,  C07D409/12

Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).