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公开(公告)号：US20240050334A1
公开(公告)日：2024-02-15
申请号：US18258267
申请日：2021-12-20
Applicant: Colgate-Palmolive Company
Inventor： Lyndsay SCHAEFFER-KORBYLO , Carl MYERS , Gokul GOVINDARAJU , Reeba PAUL
IPC: A61K8/24 , A61K8/21 , A61K8/19 , A61K8/44 , A61K33/16 , A61K33/42 , A61K47/02 , A61K47/18 , A61Q11/00
CPC classification number: A61K8/24 , A61K8/21 , A61K8/19 , A61K8/44 , A61K33/16 , A61K33/42 , A61K47/02 , A61K47/183 , A61Q11/00
Abstract: The application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous fluoride or stannous chloride or stannous pyrophosphate, potassium salts, and an amino acid (e.g., a basic amino acid) in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, and relief from dental hypersensitivity. Additionally, oral care compositions described here useful in order to naturally promote nitrate reduction from the oral microbiome, which can eventually result in systemic increases of nitric oxide in blood plasma, and can form part of an overall regimen to maintain or control blood pressure. Compositions comprise stannous fluoride, stannous chloride or stannous pyrophosphate, nitric acid or a water-soluble nitrate salt such as potassium nitrate, a water-soluble alkali metal polyphosphate such as tetrasodium pyrophosphate or trisodium polyphosphate, a basic amino aid such as arginine and more than 10 wt % water.
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12.发明公开公开(公告)号：US20240050333A1
公开(公告)日：2024-02-15
申请号：US18258251
申请日：2021-12-21
Applicant: Colgate-Palmolive Company
Inventor： Gokul GOVINDARAJU , Carl MYERS , Lyndsay SCHAEFFER-KORBYLO
Abstract: This application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous pyrophosphate and potassium salts in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, relief from dental hypersensitivity, and to treat or reduce malodor. The compositions comprise stannous pyrophosphate, nitric acid or a water-soluble nitrate salt, a water-soluble alkali metal polyphosphate and more than 10% water, by weight of the composition.
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公开(公告)号：US20220395443A1
公开(公告)日：2022-12-15
申请号：US17826961
申请日：2022-05-27
Applicant: Colgate-Palmolive Company
Inventor： Lyndsay SCHAEFFER-KORBYLO , Carl MYERS , Gokul GOVINDARAJU , Reeba PAUL
Abstract: In one aspect, the application relates to novel aqueous oral care compositions useful for combining and delivering potassium salts and a basic amino acid in a high-water composition, for example, to naturally promote nitrate reduction from the oral microbiome, which can result in systemic increases of nitric oxide in blood plasma and can form part of an overall regimen to maintain, reduce, treat or control systemic blood pressure.
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公开(公告)号：US20200289393A1
公开(公告)日：2020-09-17
申请号：US16884958
申请日：2020-05-27
Applicant: Colgate-Palmolive Company , The Forsyth Institute
Inventor： Lyndsay SCHAEFFER-KORBYLO , Jorge FRIAS-LOPEZ
Abstract: Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.
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