公开(公告)号：US20070149455A1

公开(公告)日：2007-06-28

申请号：US11614702

申请日：2006-12-21

申请人： Neil Wolfman ,  Soo-Peang Khor ,  Kathleen Tomkinson

发明人： Neil Wolfman ,  Soo-Peang Khor ,  Kathleen Tomkinson

IPC分类号： A61K38/18 ,  C07K14/475

CPC分类号： C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2319/00

摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).

摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。