公开(公告)号：US20170058293A1

公开(公告)日：2017-03-02

申请号：US15237918

申请日：2016-08-16

Applicant: Dow AgroSciences LLC

Inventor： Timothy D. Hey ,  Janna Mai Armstrong ,  Ted Letherer ,  Audrey Jane Etter ,  Meghan L. Frey ,  Haley Ellis ,  Kenneth Narva ,  Xiaoping Xu ,  Krishna M. Madduri ,  Sek Yee Tan ,  Premchand Gandra

IPC: C12N15/82 ,  A01N63/02 ,  C07K14/325

Abstract: Insecticidal toxins derived from Bacillus thuringiensis, polynucleotides encoding such toxins, use of such toxins to control plant pests, and transgenic plants that produce, and are protected, by these toxins are described.

Abstract translation: 描述了衍生自苏云金芽孢杆菌的杀虫毒素，编码这种毒素的多核苷酸，使用这些毒素来控制植物害虫，以及由这些毒素产生和保护的转基因植物。

公开(公告)号：US20170051304A1

公开(公告)日：2017-02-23

申请号：US15232876

申请日：2016-08-10

Applicant: Dow AgroSciences LLC

Inventor： Timothy D. Hey ,  Xu Xiaoping ,  Todd P. Glancy ,  Diaa Alabed ,  Sarah E. Worden ,  Nick X. Wang ,  Carla Ausmus ,  Shao-Ching Hung

IPC: C12N15/82 ,  A01N37/44 ,  C07K14/325

CPC classification number: C12N15/8286 ,  A01N63/02 ,  C07K14/325 ,  Y02A40/162

Abstract: Engineered and modified Cry6Aa insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed.

Abstract translation: 公开了工程化和修饰的Cry6Aa杀虫毒素，编码这种毒素的多核苷酸，使用这些毒素来控制害虫，以及产生这种毒素的转基因植物。

公开(公告)号：US09447153B1

公开(公告)日：2016-09-20

申请号：US13621582

申请日：2012-09-17

Applicant: Dow AgroSciences LLC

Inventor： Timothy D. Hey ,  Ignacio M. Larrinua ,  Kenneth E. Narva

IPC: C07K14/325

CPC classification number: C07K14/325 ,  A01N37/46 ,  A01N63/02 ,  C07K2319/50 ,  C12N15/8286 ,  Y02A40/162

Abstract: The present invention includes domain I modifications that improve various attributes of various Coleopteran-active Cry proteins. These attributes can include improved target pest spectrum, potency, and insect resistance management. The subject modifications can affect protoxin activation and the efficiency of pore formation, which can lead to enhanced insect intoxication.

Abstract translation: 本发明包括改进各种鞘翅目活性Cry蛋白的各种属性的I区修饰。 这些属性可以包括改进的目标害虫谱，效力和昆虫抗性管理。 受试者的修饰可以影响原毒素的活化和孔形成的效率，这可以导致昆虫中毒的增强。