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31 条记录 (耗时 0.039 秒)

    Phthalazine derivatives for treating inflammatory diseases
    12.
    发明授权
    Phthalazine derivatives for treating inflammatory diseases 失效
    用于治疗炎性疾病的酞嗪衍生物

    公开(公告)号：US07329660B2

    公开(公告)日：2008-02-12

    申请号：US11441961

    申请日：2006-05-26

    申请人： Guido Bold ,  Janet D King ,  Joerg Frei ,  Richard Heng ,  Paul W Manley ,  Bernhard Wietfeld ,  Jeanette M Wood

    发明人： Guido Bold ,  Janet D King ,  Joerg Frei ,  Richard Heng ,  Paul W Manley ,  Bernhard Wietfeld ,  Jeanette M Wood

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495

    CPC分类号： C07D401/06 ,  A61K31/501 ,  A61K31/502 ,  C07D401/14

    摘要： The invention relates to the treatment of leukemias with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I, the substituents being defined in the specification; as well as to new phthalazine derivatives; processes for the preparation thereof; the application thereof in a process for the treatment of the human or animal body; the use thereof for the treatment of a disease, especially a disease caused by ocular neovascularization, such as age-related macula degeneration or diabetic retinopathy, or other diseases that respond to the inhibition of tyrosine kinases, such as a proliferative disease; a method for the treatment of such disease in mammals; and the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment especially of a disease as mentioned above.

    摘要翻译： 本发明涉及用式I的VEGF受体酪氨酸激酶的活性抑制剂治疗白血病，所述取代基在说明书中定义; 以及新的酞嗪衍生物; 制备方法; 其用于治疗人或动物体的过程中的应用; 其用于治疗疾病，特别是由眼睛新生血管形成引起的疾病，例如年龄相关性黄斑变性或糖尿病性视网膜病，或其它对酪氨酸激酶（例如增殖性疾病）的抑制作用的疾病; 哺乳动物治疗这种疾病的方法; 以及这种化合物用于制造特别是上述疾病的药物制剂的用途。

    Phthalazine derivatives for treating inflammatory diseases
    17.
    发明授权
    Phthalazine derivatives for treating inflammatory diseases 失效
    用于治疗炎性疾病的酞嗪衍生物

    公开(公告)号：US06686347B2

    公开(公告)日：2004-02-03

    申请号：US09964025

    申请日：2001-09-26

    申请人： Guido Bold ,  Janet Dawson King ,  Jörg Frei ,  Richard Heng ,  Paul William Manley ,  Bernhard Wietfeld ,  Jeanette Marjorie Wood

    发明人： Guido Bold ,  Janet Dawson King ,  Jörg Frei ,  Richard Heng ,  Paul William Manley ,  Bernhard Wietfeld ,  Jeanette Marjorie Wood

    IPC分类号： A61K3133

    CPC分类号： C07D401/06 ,  A61K31/501 ,  A61K31/502 ,  C07D401/14

    摘要： The invention relates to the treatment of an inflammatory disease, especially an inflammatory rheumatoid or rheumatic disease, and/or pain with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I, the substituents being defined in the specification; as well as to new phthalazine derivatives; processes for the preparation thereof; the application thereof in a process for the treatment of the human or animal body; the use thereof for the treatment of a disease, especially a disease caused by ocular neovascularization, such as age-related macula degeneration or diabetic retinopathy, or other diseases that respond to the inhibition of tyrosine kinases, such as a proliferative disease; a method for the treatment of such disease in mammals; and the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment especially of a disease as mentioned above.

    摘要翻译： 本发明涉及治疗炎症性疾病，特别是炎性类风湿病或风湿性疾病，和/或具有式I的VEGF受体酪氨酸激酶的活性抑制剂的疼痛，所述取代基在本说明书中定义;以及 新的酞嗪衍生物; 制备方法; 其用于治疗人或动物体的过程中的应用; 其用于治疗疾病，特别是由眼睛新生血管形成引起的疾病，例如年龄相关性黄斑变性或糖尿病性视网膜病，或其它对酪氨酸激酶（例如增殖性疾病）的抑制作用的疾病; 哺乳动物治疗这种疾病的方法; 以及这种化合物用于制造特别是上述疾病的药物制剂的用途。

    Etherified fluorescein compounds
    20.
    发明授权
    Etherified fluorescein compounds 失效
    醚化氟化物化合物

    公开(公告)号：US5055595A

    公开(公告)日：1991-10-08

    申请号：US435876

    申请日：1989-11-14

    申请人： Bernhard Wietfeld

    发明人： Bernhard Wietfeld

    IPC分类号： B41M5/145 ,  B41M5/327 ,  C07D493/10 ,  C09B11/28

    CPC分类号： B41M5/1455 ,  B41M5/3275 ,  C07D493/10

    摘要： Etherified fluorescein compounds of the general formula ##STR1## in which X.sub.1 is alkyl having 4 to 12 carbon atoms or cycloalkyl and X.sub.2 is alkyl which is unsubstituted or substituted by halogen, hydroxyl, cyano or lower alkoxy, or cycloalkyl, the rings A and B, independently of one another, are unsubstituted or substituted by halogen, lower alkyl or lower alkoxy, and the ring D is unsubstituted or substituted by halogen, nitro, lower alkyl, lower alkoxy, lower alkylthio, lower alkoxycarbonyl, amino, mono-lower alkylamino or di-lower alkylamino, with the exception that X.sub.1 and X.sub.2 are not at the same time n-butyl.These novel lactone compounds are particularly suitable for use a color formers in pressure-sensitive or heat-sensitive recording materials and they produce intense yellow, orange or rose-pink colorations.

    摘要翻译： 醚化的通式为其中X 1为具有4至12个碳原子的烷基或环烷基且X 2为未取代或被卤素，羟基，氰基或低级烷氧基或环烷基取代的烷基的化合物，其中环 A和B彼此独立地是未取代的或被卤素，低级烷基或低级烷氧基取代，环D是未取代的或被卤素，硝基，低级烷基，低级烷氧基，低级烷硫基，低级烷氧羰基，氨基，单 - 低级烷基氨基或二低级烷基氨基，除了X1和X2不是同时为正丁基。 这些新颖的内酯化合物特别适用于压敏或热敏记录材料中的成色剂，并且它们产生强烈的黄色，橙色或玫瑰色 - 粉红色着色。