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    Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide
    3.
    发明授权
    Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide 失效
    盐形式的4-（4-甲基哌嗪-1-基甲基）-N- [4-甲基-3-（4-吡啶-3-基）嘧啶-2-基氨基）苯基] - 苯甲酰胺

    公开(公告)号：US08513256B2

    公开(公告)日：2013-08-20

    申请号：US13368811

    申请日：2012-02-08

    申请人： Hans Michael Bürger ,  Paul William Manley ,  Michael Mutz

    发明人： Hans Michael Bürger ,  Paul William Manley ,  Michael Mutz

    IPC分类号： A61K31/497 ,  A61K31/505 ,  C07D403/14 ,  C07D239/02 ,  C07D401/14

    CPC分类号： C07D401/04

    摘要： The present invention relates to acid addition salts of 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide, which are selected from the group consisting of a tartrate salt, such as a (D)(−) tartrate salt or a (L)(+) tartrate salt, a hydrochloride salt, a citrate salt, a malate salt, a fumarate salt, a succinate salt, a benzoate salt, a benzenesulfonate salt, a pamoate salt, a formate salt, a malonate salt, a 1,5-naphthalenedisulfonate salt, a salicylate salt, a cyclohexanesulfamate salt, a lactate salt, a mandelate salt, aq glutarate salt, an adipate salt, a squarate salt, a vanillate salt, an oxaloacetate salt, an ascorbate salt and a sulfate salt.

    摘要翻译： 本发明涉及4 - [（4-甲基-1-哌嗪基）甲基] -N- [4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基]苯基的酸加成盐 （D）（ - ）酒石酸盐或（L）（+）酒石酸盐，盐酸盐，柠檬酸盐，苹果酸盐等的酒石酸盐， 富马酸盐，琥珀酸盐，苯甲酸盐，苯磺酸盐，双羟萘酸盐，甲酸盐，丙二酸盐，1,5-萘二磺酸盐，水杨酸盐，环己烷氨基磺酸盐，乳酸盐，扁桃酸盐 盐，戊二酸水杨酸盐，己二酸盐，方酸盐，香草酸盐，草酰乙酸盐，抗坏血酸盐和硫酸盐。

    USE OF C-SRC INHIBITORS ALONE OR IN COMBINATION WITH STI571 FOR THE TREATMENT OF LEUKAEMIA
    7.
    发明申请
    USE OF C-SRC INHIBITORS ALONE OR IN COMBINATION WITH STI571 FOR THE TREATMENT OF LEUKAEMIA 失效
    使用C-SRC抑制剂或与STI571组合用于治疗白血病

    公开(公告)号：US20090227608A1

    公开(公告)日：2009-09-10

    申请号：US12466186

    申请日：2009-05-14

    申请人： Nicholas J. Donato ,  Doriano Fabbro ,  Paul William Manley ,  Jurgen Mestan ,  Markus Warmuth ,  Michael Hallek ,  Moshe Talpaz ,  Ji Wu

    发明人： Nicholas J. Donato ,  Doriano Fabbro ,  Paul William Manley ,  Jurgen Mestan ,  Markus Warmuth ,  Michael Hallek ,  Moshe Talpaz ,  Ji Wu

    IPC分类号： A61K31/519 ,  A61P35/00

    CPC分类号： A61K35/02 ,  A61K31/506 ,  A61K31/519

    摘要： The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.

    摘要翻译： 本发明涉及一种组合，其包含（a）至少一种降低c-Src活性的化合物和（b）N- {5- [4-（4-甲基 - 哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺或其单甲磺酸盐; 包含所述组合的药物组合物; 以及治疗具有白血病，特别是慢性骨髓性白血病的温血动物的方法，包括向所述动物施用至少一种抑制Src激酶家族成员，Btk激酶家族，Tec激酶家族的活性的化合物或 Raf激酶抑制剂，特别是抑制c-Src蛋白酪氨酸激酶活性或同时抑制c-Src蛋白酪氨酸激酶活性和Bcr-Abl酪氨酸激酶活性，单独或与Bcr-Abl抑制剂组合，特别是N - {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺。

    4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives
    8.
    发明授权
    4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives 失效
    4-氨基-5-苯基-7-环丁基 - 吡咯并（2,3-d）嘧啶衍生物

    公开(公告)号：US07326699B2

    公开(公告)日：2008-02-05

    申请号：US10477594

    申请日：2002-05-13

    申请人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria ,  Paul William Manley

    发明人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria ,  Paul William Manley

    IPC分类号： C07D417/06 ,  C07D417/12 ,  C07D487/04 ,  C07D403/06 ,  C07D403/12 ,  C07D413/06 ,  C07D413/12 ,  A61K31/55 ,  A61K31/541 ,  A61K31/5355 ,  A61K31/497 ,  A61K31/519 ,  A61P35/04

    CPC分类号： C07D487/04

    摘要： The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof-alone or in combination with one or more other pharmaceutically active compounds-for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.

    摘要翻译： 本发明涉及新的4-氨基-5-苯基-7-环丁基 - 吡咯并[2,3-d]嘧啶衍生物，其制备方法及其在治疗人或动物体的方法中的应用， 其用途 - 单独使用或与一种或多种其它药学活性化合物组合用于治疗疾病，特别是增殖性疾病，例如肿瘤疾病，哺乳动物，特别是人类中的这些疾病的治疗方法， 以及这种化合物单独使用或与一种或多种其它药学活性化合物组合的用途，用于制备特别是增殖性疾病如肿瘤的药物组合物（药物）。