公开(公告)号：US09585681B2

公开(公告)日：2017-03-07

申请号：US12883087

申请日：2010-09-15

申请人： Donald J. Eaton ,  Thomas R. Tice ,  David B. Downie ,  Patrick A. Arensdorf ,  Rodney A. Brenneman ,  Danielle L. Biggs

发明人： Donald J. Eaton ,  Thomas R. Tice ,  David B. Downie ,  Patrick A. Arensdorf ,  Rodney A. Brenneman ,  Danielle L. Biggs

IPC分类号： A61B17/24 ,  A61K9/00 ,  A61K9/70 ,  A61K31/573 ,  A61K31/58 ,  A61F2/18 ,  A61K9/16

CPC分类号： A61B17/24 ,  A61F2/186 ,  A61K9/0043 ,  A61K9/1647 ,  A61K9/70 ,  A61K31/573 ,  A61K31/58 ,  A61K47/14 ,  A61K47/34 ,  A61M29/00

摘要： Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.

摘要翻译： 这里描述了用于治疗鼻旁窦状况的鼻旁窦装置。 这些装置包括空腔构件，口部构件和鼻部。 空腔构件，口腔构件和鼻部分中的一个或多个可以递送用于持续释放的活性剂以治疗鼻旁窦状况。 由于功能性内镜鼻窦手术（FESS）和鼻鼻窦炎，示例性的鼻旁窦状况是鼻窦炎症。

公开(公告)号：US08740839B2

公开(公告)日：2014-06-03

申请号：US12883071

申请日：2010-09-15

申请人： Donald J. Eaton ,  Thomas R. Tice ,  David B. Downie ,  Patrick A. Arensdorf ,  Rodney A. Brenneman ,  Danielle L. Biggs

发明人： Donald J. Eaton ,  Thomas R. Tice ,  David B. Downie ,  Patrick A. Arensdorf ,  Rodney A. Brenneman ,  Danielle L. Biggs

IPC分类号： A61M31/00

CPC分类号： A61B17/24 ,  A61F2/186 ,  A61K9/0043 ,  A61K9/1647 ,  A61K9/70 ,  A61K31/573 ,  A61K31/58 ,  A61K47/14 ,  A61K47/34 ,  A61M29/00

摘要： Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.

公开(公告)号：US07686798B2

公开(公告)日：2010-03-30

申请号：US12419943

申请日：2009-04-07

申请人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

IPC分类号： A61M31/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

公开(公告)号：US07544192B2

公开(公告)日：2009-06-09

申请号：US10800162

申请日：2004-03-12

申请人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

IPC分类号： A61M31/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

摘要翻译： 本发明提供用于治疗鼻窦炎的可生物降解植入物。 可生物降解的植入物具有尺寸，形状，密度，粘度和/或粘膜粘附性，防止在预期治疗期间鼻窦的粘膜纤毛内衬基本上被清除。 可生物降解的植入物包括持续释放治疗剂，例如抗生素，甾族抗炎药或两者。 可生物降解的植入物可以采取各种形式，例如棒，丸，珠，条或微粒，并且可以递送到各种药学上可接受的载体中的窦内。

公开(公告)号：US07713255B2

公开(公告)日：2010-05-11

申请号：US12419930

申请日：2009-04-07

申请人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

IPC分类号： A61M31/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

公开(公告)号：US07662141B2

公开(公告)日：2010-02-16

申请号：US12419925

申请日：2009-04-07

申请人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

IPC分类号： A61M31/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

公开(公告)号：US08109918B2

公开(公告)日：2012-02-07

申请号：US12479794

申请日：2009-06-06

申请人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

IPC分类号： A61M31/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

摘要翻译： 本发明提供用于治疗鼻窦炎的可生物降解植入物。 可生物降解的植入物具有尺寸，形状，密度，粘度和/或粘膜粘附性，防止在预期治疗期间鼻窦的粘膜纤毛内衬基本上被其清除。 可生物降解的植入物包括持续释放治疗剂，例如抗生素，甾族抗炎药或两者。 可生物降解的植入物可以采取各种形式，例如棒，丸，珠，条或微粒，并且可以递送到各种药学上可接受的载体中的窦内。

公开(公告)号：US20090192489A1

公开(公告)日：2009-07-30

申请号：US12419927

申请日：2009-04-07

申请人： Donald J. Eaton ,  Mary Lynn Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary Lynn Moran ,  Rodney Brenneman

IPC分类号： A61M5/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

公开(公告)号：US07691094B2

公开(公告)日：2010-04-06

申请号：US12419937

申请日：2009-04-07

申请人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

IPC分类号： A61M31/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

摘要翻译： 本发明提供用于治疗鼻窦炎的可生物降解植入物。 可生物降解的植入物具有尺寸，形状，密度，粘度和/或粘膜粘附性，防止在预期治疗期间鼻窦的粘膜纤毛内衬基本上被其清除。 可生物降解的植入物包括持续释放治疗剂，例如抗生素，甾族抗炎药或两者。 可生物降解的植入物可以采取各种形式，例如棒，丸，珠，条或微粒，并且可以递送到各种药学上可接受的载体中的窦内。

公开(公告)号：US07662142B2

公开(公告)日：2010-02-16

申请号：US12419927

申请日：2009-04-07

申请人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

发明人： Donald J. Eaton ,  Mary L. Moran ,  Rodney Brenneman

IPC分类号： A61M31/00

CPC分类号： A61M31/007 ,  A61K9/0024 ,  A61K9/0043 ,  A61K31/43 ,  A61K31/573 ,  A61K31/58 ,  A61K47/34

摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.