公开(公告)号：US20150252085A1

公开(公告)日：2015-09-10

申请号：US14683738

申请日：2015-04-10

Applicant: EMD Millipore Corporation

Inventor： Shari Spector ,  Robert Smith ,  Joe Orlando ,  Nanying Bian

IPC: C07K14/31 ,  C07K16/12 ,  C07K1/22

CPC classification number: C07K14/31 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3272 ,  B01J20/3274 ,  C07K1/22 ,  C07K16/1271 ,  C07K2319/21

Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.

公开(公告)号：US09018305B2

公开(公告)日：2015-04-28

申请号：US14534999

申请日：2014-11-06

Applicant: EMD Millipore Corporation

Inventor： Shari Spector ,  Robert Smith ,  Joe Orlando ,  Nanying Bian

IPC: B01J20/286 ,  C07K1/22 ,  C07K14/31 ,  C07K16/12

CPC classification number: C07K14/31 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3272 ,  B01J20/3274 ,  C07K1/22 ,  C07K16/1271 ,  C07K2319/21

Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.

Abstract translation: 本发明涉及包括基于免疫球蛋白结合蛋白（例如金黄色葡萄球菌蛋白A（SpA））的一个或多个结构域的配体的色谱基质，以及使用它们的方法。

公开(公告)号：US20140046037A1

公开(公告)日：2014-02-13

申请号：US14061080

申请日：2013-10-23

Applicant: EMD Millipore Corporation

Inventor： Shari Spector

IPC: C07K16/12

CPC classification number: C07K16/1271 ,  B01J20/286 ,  B01J20/3274 ,  C07K1/22 ,  C07K14/31

Abstract: The present invention relates to modified immunoglobulin-binding proteins, e.g., Staphylococcus protein A, having improved binding specificity for immunoglobulins and methods of making and using the same.

Abstract translation: 本发明涉及对免疫球蛋白具有改善的结合特异性的修饰的免疫球蛋白结合蛋白，例如葡萄球菌蛋白A，以及制备和使用免疫球蛋白的方法。