公开(公告)号：US20120094008A1

公开(公告)日：2012-04-19

申请号：US13272874

申请日：2011-10-13

申请人： Alexander Grinberg ,  Andre Skirtach ,  Dmitry V. Volodkin ,  Helmuth Möhwald ,  Stephan Schmidt ,  Regine von Klitzing

发明人： Alexander Grinberg ,  Andre Skirtach ,  Dmitry V. Volodkin ,  Helmuth Möhwald ,  Stephan Schmidt ,  Regine von Klitzing

IPC分类号： A61K9/16 ,  C07K14/62 ,  C07K1/00

CPC分类号： A61K9/1688

摘要： This invention describes novel methods for fabricating nano/micro particles and capsules through template decomposition which incorporates the to-be-encapsulated molecules which are precipitated in pores of particles or in solution, i.e. below their isoelectric point, drying or by solvent adjustment methods. The encapsulation process can be followed by a deposition or adsorption of a protective shell that regulates release of the encapsulated material. The encapsulation, inclusion, manipulation, and release of various materials and bio-materials is to be conducted by delivery vehicles which are particles and capsules with sizes in the range of nanometers and micrometers. They can possess multicompartment and anisotropic geometries and can carry one or several types of various molecules. This invention can potentially be used for controlled delivery, manipulation, and release in a variety of applications requiring delivery vehicles such as cell cultures, in-vivo, subcutaneous incorporation, injection, spray-inhalation and planar surfaces, films, and stents.

摘要翻译： 本发明描述了通过模板分解制造纳米/微粒和胶囊的新方法，其中包含在颗粒或溶液中沉淀的待包封分子，即低于其等电点，干燥或通过溶剂调节方法。 封装过程之后可以是调节封装材料释放的保护壳的沉积或吸附。 各种材料和生物材料的包封，包合，操作和释放应由粒度在纳米和微米范围内的颗粒和胶囊的输送载体进行。 它们可以具有多室和各向异性几何形状，并且可以携带一种或几种类型的各种分子。 本发明可潜在地用于需要递送载体如细胞培养物，体内，皮下并入，注射，喷雾吸入和平面表面，膜和支架的各种应用中的受控递送，操作和释放。