公开(公告)号：US09340676B2

公开(公告)日：2016-05-17

申请号：US12282185

申请日：2007-03-07

Applicant: Dmitry Shchukin ,  Helmuth Möhwald ,  Mário Guerreiro Silva Ferreira ,  Mikhail Zheludkevich

Inventor： Dmitry Shchukin ,  Helmuth Möhwald ,  Mário Guerreiro Silva Ferreira ,  Mikhail Zheludkevich

IPC: C04B9/02 ,  C04B14/02 ,  C08K9/10 ,  C09D5/08 ,  B05D5/00 ,  C04B14/04 ,  C04B14/36 ,  C09C1/36 ,  B82Y30/00 ,  C09C1/30 ,  C09C3/10 ,  C09D7/12 ,  C04B20/10 ,  C08K3/22 ,  C08K7/24 ,  C08K9/08 ,  C04B111/26

CPC classification number: C09C1/3676 ,  B82Y30/00 ,  C01P2004/13 ,  C01P2004/34 ,  C01P2004/62 ,  C01P2004/64 ,  C04B20/1029 ,  C04B2111/26 ,  C08K3/22 ,  C08K7/24 ,  C08K9/08 ,  C09C1/3072 ,  C09C3/10 ,  C09D5/082 ,  C09D7/40 ,  C09D7/67 ,  C09D7/68 ,  C04B2103/54

Abstract: A corrosion inhibiting pigment includes nanoscale reservoirs (nanoreservoirs) of corrosion inhibitor for active corrosion protection of metallic products and structures, wherein the nanoreservoirs include a polymer or polyelectrolyte shell which is sensitive to a specific trigger and capable of releasing the inhibitor after action of the trigger. An anti-corrosive coating with self-healing properties includes the pigment, methods for preparing the pigment, in particular by layer-by-layer deposition, as well as methods of use of the pigment.

Abstract translation: 腐蚀抑制颜料包括用于金属产品和结构的主动腐蚀保护的防腐蚀剂的纳米储存器（纳米储存器），其中纳米储存器包括对特定触发器敏感并且能够在触发器作用之后释放抑制剂的聚合物或聚电解质外壳 。 具有自愈性质的抗腐蚀涂层包括颜料，颜料的制备方法，特别是通过逐层沉积，以及颜料的使用方法。

公开(公告)号：US07101575B2

公开(公告)日：2006-09-05

申请号：US10376386

申请日：2003-02-27

Applicant: Edwin Donath ,  Gleb B. Sukhorukov ,  Karl-Heinz Lerche ,  Andreas Voigt ,  Hans Bäumler ,  Frank Caruso ,  Helmuth Möhwald

Inventor： Edwin Donath ,  Gleb B. Sukhorukov ,  Karl-Heinz Lerche ,  Andreas Voigt ,  Hans Bäumler ,  Frank Caruso ,  Helmuth Möhwald

IPC: A61K9/48

CPC classification number: A61K9/5138 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5052 ,  A61K9/5073 ,  A61K9/5089 ,  A61K9/51 ,  A61K9/5192 ,  B01J13/02 ,  B01J13/22

Abstract: The invention relates to capsules coated with a polyelectrolyte shell and methods for the production thereof.

公开(公告)号：US07056554B2

公开(公告)日：2006-06-06

申请号：US10343670

申请日：2001-08-01

Applicant: Andreas Voigt ,  Gleb Sukhorukov ,  Igor Radtchenko ,  Alexei Antipov ,  Edwin Donath ,  Helmuth Möhwald

Inventor： Andreas Voigt ,  Gleb Sukhorukov ,  Igor Radtchenko ,  Alexei Antipov ,  Edwin Donath ,  Helmuth Möhwald

IPC: B05D7/02 ,  B01J13/22

CPC classification number: A61K9/5192 ,  A61K9/5026 ,  A61K9/5089 ,  A61K9/5138 ,  B01J13/02 ,  B01J13/10 ,  B01J13/22 ,  Y10T428/2984

Abstract: The invention concerns a method for producing nanocapsules and microcapsules comprising a polyelectrolyte shell by surface precipitation from the solution, by applying a shell to template particles comprising the steps (a) providing a dispersion of template particles of suitable size in a salt-containing liquid phase which contains the components required to form the shell in a dissolved form and (b) precipitating the components from the liquid phase onto the template particles under conditions which enable the formation of a shell around the template particles that has a thickness of from 1 to 100 nm.

公开(公告)号：US06833192B1

公开(公告)日：2004-12-21

申请号：US10018325

申请日：2002-03-25

Applicant: Frank Caruso ,  Dieter Trau ,  Helmuth Möhwald ,  Reinhard Renneberg

Inventor： Frank Caruso ,  Dieter Trau ,  Helmuth Möhwald ,  Reinhard Renneberg

IPC: B32B516

CPC classification number: A61K9/5026 ,  C30B29/58 ,  C30B33/00 ,  Y10S428/90 ,  Y10T428/2991

Abstract: The invention refers to a new process for preparing coated crystals by coating crystal template particles with alternating layers of oppositely charged polyelectrolytes and/or nanoparticles.

Abstract translation: 本发明涉及通过用相反电荷的聚电解质和/或纳米颗粒的交替层涂覆晶体模板颗粒来制备涂层晶体的新方法。

公开(公告)号：US06699501B1

公开(公告)日：2004-03-02

申请号：US09743367

申请日：2001-03-07

Applicant: Björn Neu ,  Hans Bäumler ,  Edwin Donath ,  Sergio Moya ,  Gleb Sukhobukov ,  Helmuth Möhwald ,  Frank Caruso

Inventor： Björn Neu ,  Hans Bäumler ,  Edwin Donath ,  Sergio Moya ,  Gleb Sukhobukov ,  Helmuth Möhwald ,  Frank Caruso

IPC: A61K914

CPC classification number: B01J13/02 ,  A61K9/5089 ,  B01J13/22

Abstract: The invention relates to a method for producing capsules provided with a polyelectrolyte covering, and to the capsules obtained using this method.

Abstract translation: 本发明涉及一种制备具有聚电解质覆盖物的胶囊的方法，以及使用该方法获得的胶囊。

公开(公告)号：US08168226B2

公开(公告)日：2012-05-01

申请号：US11502180

申请日：2006-08-10

Applicant: Edwin Donath ,  Gleb B. Sukhorukov ,  Karl-Heinz Lerche ,  Andreas Voigt ,  Hans Bäumler ,  Frank Caruso ,  Helmuth Möhwald

Inventor： Edwin Donath ,  Gleb B. Sukhorukov ,  Karl-Heinz Lerche ,  Andreas Voigt ,  Hans Bäumler ,  Frank Caruso ,  Helmuth Möhwald

IPC: A61K9/16 ,  A61K9/28 ,  A61K9/14

CPC classification number: A61K9/5138 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5052 ,  A61K9/5073 ,  A61K9/5089 ,  A61K9/51 ,  A61K9/5192 ,  B01J13/02 ,  B01J13/22

Abstract: The invention relates to capsules coated with a polyelectrolyte shell and methods for the production thereof.

Abstract translation: 本发明涉及涂覆有聚电解质壳的胶囊及其生产方法。

公开(公告)号：US20120094008A1

公开(公告)日：2012-04-19

申请号：US13272874

申请日：2011-10-13

Applicant: Alexander Grinberg ,  Andre Skirtach ,  Dmitry V. Volodkin ,  Helmuth Möhwald ,  Stephan Schmidt ,  Regine von Klitzing

Inventor： Alexander Grinberg ,  Andre Skirtach ,  Dmitry V. Volodkin ,  Helmuth Möhwald ,  Stephan Schmidt ,  Regine von Klitzing

IPC: A61K9/16 ,  C07K14/62 ,  C07K1/00

CPC classification number: A61K9/1688

Abstract: This invention describes novel methods for fabricating nano/micro particles and capsules through template decomposition which incorporates the to-be-encapsulated molecules which are precipitated in pores of particles or in solution, i.e. below their isoelectric point, drying or by solvent adjustment methods. The encapsulation process can be followed by a deposition or adsorption of a protective shell that regulates release of the encapsulated material. The encapsulation, inclusion, manipulation, and release of various materials and bio-materials is to be conducted by delivery vehicles which are particles and capsules with sizes in the range of nanometers and micrometers. They can possess multicompartment and anisotropic geometries and can carry one or several types of various molecules. This invention can potentially be used for controlled delivery, manipulation, and release in a variety of applications requiring delivery vehicles such as cell cultures, in-vivo, subcutaneous incorporation, injection, spray-inhalation and planar surfaces, films, and stents.

Abstract translation: 本发明描述了通过模板分解制造纳米/微粒和胶囊的新方法，其中包含在颗粒或溶液中沉淀的待包封分子，即低于其等电点，干燥或通过溶剂调节方法。 封装过程之后可以是调节封装材料释放的保护壳的沉积或吸附。 各种材料和生物材料的包封，包合，操作和释放应由粒度在纳米和微米范围内的颗粒和胶囊的输送载体进行。 它们可以具有多室和各向异性几何形状，并且可以携带一种或几种类型的各种分子。 本发明可潜在地用于需要递送载体如细胞培养物，体内，皮下并入，注射，喷雾吸入和平面表面，膜和支架的各种应用中的受控递送，操作和释放。

公开(公告)号：US08092836B2

公开(公告)日：2012-01-10

申请号：US11502182

申请日：2006-08-10

Applicant: Edwin Donath ,  Gleb B. Sukhorukov ,  Karl-Heinz Lerche ,  Andreas Voigt ,  Hans Bäumler ,  Frank Caruso ,  Helmuth Möhwald

Inventor： Edwin Donath ,  Gleb B. Sukhorukov ,  Karl-Heinz Lerche ,  Andreas Voigt ,  Hans Bäumler ,  Frank Caruso ,  Helmuth Möhwald

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/48

CPC classification number: A61K9/5138 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5052 ,  A61K9/5073 ,  A61K9/5089 ,  A61K9/51 ,  A61K9/5192 ,  B01J13/02 ,  B01J13/22

Abstract: The invention relates to capsules coated with a polyelectrolyte shell and methods for the production thereof.

公开(公告)号：US06479146B1

公开(公告)日：2002-11-12

申请号：US09646398

申请日：2000-11-07

Applicant: Frank Caruso ,  Rachel Anne Caruso ,  Edwin Donath ,  Helmuth Möhwald ,  Gleb Sukhorukov

Inventor： Frank Caruso ,  Rachel Anne Caruso ,  Edwin Donath ,  Helmuth Möhwald ,  Gleb Sukhorukov

IPC: B32B516

CPC classification number: B01J13/22 ,  A61K9/5089 ,  A61K9/5192 ,  B01J13/02 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2998

Abstract: The invention refers to a new process for preparing coated particles and hollow shells by coating colloidal particles with alternating layers of oppositely charged nanoparticles and polyelectrolytes and optionally removing the colloidal cores.

Abstract translation: 本发明涉及通过涂覆具有相反电荷的纳米颗粒和聚电解质的交替层并且任选地除去胶体核心的胶体颗粒来制备涂覆颗粒和中空壳的新方法。

公开(公告)号：US20130210969A1

公开(公告)日：2013-08-15

申请号：US13699439

申请日：2011-05-23

Applicant: Dmitry O. Grigoriev ,  Dmitry Shchukin ,  Helmuth Möhwald

Inventor： Dmitry O. Grigoriev ,  Dmitry Shchukin ,  Helmuth Möhwald

IPC: B65D25/00 ,  C08K5/3435 ,  C08K5/3462 ,  C08K5/33 ,  C08K5/3437 ,  C08K5/41 ,  C08K5/42 ,  C08K3/20

CPC classification number: B65D25/00 ,  B01J13/02 ,  C08K3/20 ,  C08K5/33 ,  C08K5/3435 ,  C08K5/3437 ,  C08K5/3462 ,  C08K5/41 ,  C08K5/42 ,  C09D5/1625 ,  C10M171/06 ,  C10M173/02 ,  C10M2201/062 ,  C10M2201/085 ,  C10M2203/022 ,  C10M2205/04 ,  C10M2207/021 ,  C10M2207/08 ,  C10M2207/281 ,  C10M2207/285 ,  C10M2209/04 ,  C10M2209/103 ,  C10M2215/04 ,  C10M2215/14 ,  C10M2215/221 ,  C10M2217/045 ,  C10M2219/042 ,  C10M2219/044 ,  C10M2219/066 ,  C10M2219/09 ,  C10M2227/04 ,  C10M2227/09 ,  C10N2210/06 ,  C10N2220/082 ,  C10N2230/12 ,  C10N2250/16 ,  C10N2270/00 ,  C23F11/00 ,  D06M23/12 ,  D06M2200/12

Abstract: Nano- or microsized containers include either a water immiscible or sparingly miscible core dispersible in aqueous dispersion medium or a water miscible core dispersible in non-aqueous dispersion medium and a core-soluble active agent selected from the group consisting of corrosion inhibitors, catalysts, accelerators of catalysts, adhesives, sealants, polymerizable compounds (monomers), surfactants, lubricants, antifouling agents, water repelling materials and their mixtures, and a stimulus-sensitive polymer/polyelectrolyte shell that encapsulates the core-soluble active agent and releases the encapsulated agent in response to an external stimulus selected from the group consisting of humidity, ionic strength, pH, temperature, mechanical stress, constant and alternating magnetic or electromagnetic fields, corrosion products, electric current, and electrochemical potential.

Abstract translation: 纳米或微尺寸容器包括可分散在水分散介质中的水不混溶或可微混溶的核，或可分散在非水分散介质中的水混溶性核心和选自腐蚀抑制剂，催化剂，促进剂的核心可溶性活性剂 的催化剂，粘合剂，密封剂，可聚合化合物（单体），表面活性剂，润滑剂，防污剂，排斥材料及其混合物，以及刺激敏感的聚合物/聚电解质壳，其包封芯可溶性活性剂并将包封的试剂释放 响应于从湿度，离子强度，pH，温度，机械应力，恒定和交替磁场或电磁场，腐蚀产物，电流和电化学电位组成的组中选择的外部刺激。