公开(公告)号：US11486879B2

公开(公告)日：2022-11-01

申请号：US16583870

申请日：2019-09-26

Applicant: FUJIFILM Corporation

Inventor： Hiroyuki Chiku ,  Tomoaki Yoshioka ,  Kousuke Watanabe ,  Kazuhiro Hamada ,  Kouitsu Sasaki

IPC: G01N33/58 ,  G01N33/543 ,  C07F5/02 ,  C09K11/06

Abstract: An object of the present invention is to provide a kit and a method capable of achieving high-precision measurement of a measurement target substance in a biological sample in a wide concentration range from a low concentration to a high concentration by sufficiently avoiding the influence of antibodies such as anti-serum albumin antibody present in blood. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, the kit including: a labeled particle having a first binding substance capable of binding to the measurement target substance and having a first blocking agent; and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance and having a second blocking agent, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle, and the first blocking agent and the second blocking agent are different from each other. Each symbol in Formula (1) has the meaning described in the present specification.

公开(公告)号：US10816469B2

公开(公告)日：2020-10-27

申请号：US16115593

申请日：2018-08-29

Applicant: FUJIFILM Corporation

Inventor： Noriyuki Kasagi ,  Hiroyuki Chiku

IPC: G01N21/64 ,  G01N33/531 ,  G01N33/543 ,  G01N33/553

Abstract: An object of the present invention is to provide a kit and a method by which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy while avoiding the influence of an antibody such as an anti-serum albumin antibody present in blood. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including: a labeled particle that has a first binding substance capable of binding to the substance to be measured, and a first blocking agent; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, and a second blocking agent, in which the first blocking agent and the second blocking agent are different from each other, is provided.