公开(公告)号：US20070098641A1

公开(公告)日：2007-05-03

申请号：US11265728

申请日：2005-11-02

申请人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

发明人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

IPC分类号： A61K49/04

CPC分类号： C09C1/00 ,  A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01P2004/04 ,  C01P2004/64 ,  C09C1/24 ,  C09C3/08 ,  C09C3/12

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

公开(公告)号：US20060093555A1

公开(公告)日：2006-05-04

申请号：US11263714

申请日：2005-11-01

申请人： Andrew Torres ,  Brian Bales ,  Peter Bonitatebus ,  Amit Kulkarni ,  William Dixon ,  Lisa Schoonmaker ,  Patrick Malenfant ,  Anton Beletskii ,  Matthew Morrison

发明人： Andrew Torres ,  Brian Bales ,  Peter Bonitatebus ,  Amit Kulkarni ,  William Dixon ,  Lisa Schoonmaker ,  Patrick Malenfant ,  Anton Beletskii ,  Matthew Morrison

IPC分类号： A61K49/10

CPC分类号： A61K49/1848 ,  A61K49/186 ,  B82Y5/00

摘要： The present invention is directed to the field of magnetic resonance imaging (MRI) using superparamagnetic iron oxide (SPIO) agents. In particular, the present invention is directed to cationic, nonagglomerated, nontoxic SPIO agents, methods for imaging conditions associated with inflammatory responses using the disclosed SPIO agents, and methods for managing inflammatory conditions using the disclosed SPIO agents.

摘要翻译： 本发明涉及使用超顺磁性氧化铁（SPIO）试剂的磁共振成像（MRI）领域。 特别地，本发明涉及阳离子，非团聚的，无毒的SPIO试剂，使用所公开的SPIO试剂对与炎症反应相关的成像条件的方法，以及使用所公开的SPIO试剂来治疗炎性病症的方法。