公开(公告)号：US06458567B1

公开(公告)日：2002-10-01

申请号：US09431419

申请日：1999-11-01

申请人： Jack R. Barber ,  Peter J. Welch ,  Richard Tritz ,  SoonPin Yei ,  Mang Yu

发明人： Jack R. Barber ,  Peter J. Welch ,  Richard Tritz ,  SoonPin Yei ,  Mang Yu

IPC分类号： C07H2104

CPC分类号： C12N15/1131 ,  A61K38/00 ,  C07H21/04 ,  C12N2310/111 ,  C12N2310/122 ,  C12N2799/022 ,  C12N2799/025 ,  C12N2799/027

摘要： This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (“HCV”) infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes usefull in methods of treatment and prevention of HCV infection or disease are also provided.

摘要翻译： 本发明提供用于治疗或预防生物体或受试者中的丙型肝炎病毒（“HCV”）感染或疾病的核酶以及治疗HCV感染或疾病的方法。 还提供了诸如载体，宿主细胞，编码这些核酶的DNA分子的试剂在治疗和预防HCV感染或疾病的方法中有用。

公开(公告)号：US08084036B2

公开(公告)日：2011-12-27

申请号：US10718986

申请日：2003-11-21

申请人： Mang Yu ,  Fang Fang ,  Michael Malakhov

发明人： Mang Yu ,  Fang Fang ,  Michael Malakhov

IPC分类号： A61K39/00 ,  C12N9/36

CPC分类号： B82Y5/00 ,  A61K38/47 ,  A61K38/57

摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.

摘要翻译： 本发明提供了用于预防和治疗病原体感染的新的组合物和方法。 特别地，本发明提供具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。 优选的靶细胞是上皮细胞。 本发明提供了用于预防病毒性疾病（例如流行性感冒）的组合物和方法，使用具有锚定结构域的化合物，所述化合物具有可结合与细胞外作用以干扰靶细胞的病毒感染的酶活性连接的靶细胞。 本发明还提供了用于使用具有锚定结构域的化合物来预防病毒性疾病例如流感的组合物和方法，所述化合物具有可以结合与蛋白酶抑制剂连接的靶细胞，其可以在细胞外作用以干扰靶细胞的病毒感染。