公开(公告)号：US20220344004A1

公开(公告)日：2022-10-27

申请号：US17691049

申请日：2022-03-09

Applicant: GUARDANT HEALTH, INC.

Inventor： Catalin BARBACIORU ,  Darya CHUDOVA ,  Aliaksandr ARTSIOMENKA ,  Daniel GAILE ,  Hao WANG

IPC: G16B30/10 ,  G16B20/20 ,  G16B20/10

Abstract: In implementations described herein, information derived from a sample that is derived from off-target sequences can be used to determine estimates for the copy number of tumor cells and/or the tumor fraction of a sample. Additionally, information derived from the presence of germline SNPs can be used to determine estimates for at least one of the copy number of tumor cells or the tumor fraction of a sample.

公开(公告)号：US20210398610A1

公开(公告)日：2021-12-23

申请号：US17162897

申请日：2021-01-29

Applicant: GUARDANT HEALTH, INC.

Inventor： Aliaksandr ARTSIOMENKA ,  Aaron Isaac HARDIN ,  Stephen FAIRCLOUGH ,  Marcin SIKORA ,  Catalin BARBACIORU

IPC: G16B20/20 ,  G16H10/40 ,  G16H50/70 ,  G16H20/10

Abstract: Provided herein are methods of making negative predictions. In some aspects, methods of determining that a first target nucleic acid variant is absent at a first genetic locus in a cell-free nucleic acid (cfNA) sample obtained from a subject having a given cancer type at least partially using a computer are provided. Certain of these methods include determining that the first target nucleic acid variant is not detected in the cfNA sample obtained from the subject, generating, by the computer, at least one tumor fraction based value; generating, by the computer, at least one mutual exclusivity value; and determining that the first target nucleic acid variant is absent at the first genetic locus in the cfNA sample using the tumor fraction based value and/or the mutual exclusivity value. Additional methods and related systems and computer readable media are also provided.