公开(公告)号：US20240158527A1

公开(公告)日：2024-05-16

申请号：US18410949

申请日：2024-01-11

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang KAO ,  Michael W. LAIRD ,  Melody Trexler SCHMIDT ,  Rita L. WONG ,  Daniel P. HEWITT

IPC: C07K16/28 ,  A61K39/395 ,  C07K1/14

CPC classification number: C07K16/2887 ,  A61K39/39591 ,  C07K1/14 ,  C07K2317/24

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US20200317801A1

公开(公告)日：2020-10-08

申请号：US16847309

申请日：2020-04-13

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang KAO ,  Michael W. LAIRD ,  Melody Trexler SCHMIDT ,  Rita L. WONG ,  Daniel P. HEWITT

IPC: C07K16/28 ,  A61K39/395 ,  C07K1/14

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.