-
公开(公告)号:US20190194246A1
公开(公告)日:2019-06-27
申请号:US16143917
申请日:2018-09-27
申请人: CEM Corporation
发明人: JONATHAN M. COLLINS
IPC分类号: C07K1/04 , C07K1/06 , C07K1/14 , C07K7/08 , C07K7/16 , C07K14/005 , C07K14/46 , C07K14/47 , C07K14/575 , C07K14/59 , C07K14/605 , C07K14/635 , C07K14/645 , C07K14/705 , C07K14/815 , C07K1/107 , C12N7/00 , B01J19/12
CPC分类号: C07K1/045 , B01J19/126 , B01J2204/005 , B01J2219/00058 , B01J2219/0879 , B01J2219/1248 , C07K1/04 , C07K1/063 , C07K1/1075 , C07K1/14 , C07K7/08 , C07K7/16 , C07K14/005 , C07K14/463 , C07K14/4701 , C07K14/4723 , C07K14/575 , C07K14/57572 , C07K14/59 , C07K14/605 , C07K14/635 , C07K14/645 , C07K14/705 , C07K14/815 , C12N7/00 , C12N2740/16322
摘要: An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.
-
公开(公告)号:US20180344835A1
公开(公告)日:2018-12-06
申请号:US15562167
申请日:2016-03-29
IPC分类号: A61K39/12 , C07K14/005 , C12N15/62 , C07K1/14 , G01N33/53 , G01N33/566 , A61P31/20
CPC分类号: A61K39/12 , A61K2039/5258 , A61K2039/552 , A61K2039/6075 , A61P31/20 , C07K1/14 , C07K14/005 , C07K2319/40 , C12N15/62 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2770/10022 , C12N2770/10034 , C12N2799/026 , G01N33/5308 , G01N33/566
摘要: The present invention relates to an immunogen-carrier, wherein the immunogen-carrier is preferably a virus-like particle (VLP) composed of a plurality of a modified PCV2 ORF2 protein. In particular, the present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a compliance marker for vaccines including a subunit antigen, and a DIVA (Differentiating Infected from Vaccinated Animals) system which makes it possible to differentiate between animals infected with a pathogen and animals treated with a subunit antigen derived from said pathogen.
-
公开(公告)号:US20180325118A1
公开(公告)日:2018-11-15
申请号:US15774430
申请日:2016-11-10
申请人: CHR. HANSEN A/S
摘要: The present invention relates to a process for harvesting biomass of a bacterium, and/or a lipoprotein produced by a bacterium, which exhibit antifungal and antibacterial activity against various phytopathogenic agents.
-
公开(公告)号:US20180296943A1
公开(公告)日:2018-10-18
申请号:US15955870
申请日:2018-04-18
CPC分类号: B01D17/045 , B01D17/047 , B01D17/06 , B03C5/026 , B03C11/00 , B03C2201/02 , C07K1/14 , C10G33/02 , C12N13/00 , C12N15/1003
摘要: Embodiments discussed herein relate to systems and methods for separating two or more phases of an emulsion or other mixture. The methods include providing the mixture with a net and unipolar charge (e.g., such that adjacent droplets therein acquire net and unipolar charges), thereby enhancing coalescence of like-phase droplets therein and producing, or enhancing the production of, two or more consolidated phases; and collecting the two or more consolidated phases.
-
公开(公告)号:US10053488B2
公开(公告)日:2018-08-21
申请号:US15245348
申请日:2016-08-24
申请人: SYSMEX CORPORATION
发明人: Rena Tsuruoka , Sanai Tsunokuni , Yukiko Miura , Hiroyuki Kabata
摘要: Disclosed is a method of liberating a peptide, the method comprising a step of bringing a self-aggregate of albumin containing a peptide incorporated therein into contact with a solution that contains a compound represented by Formula (I) or (II) defined in the specification at a concentration of 80 mM to 1000 mM and allowing the peptide to be liberated from the self-aggregate of albumin into the solution.
-
公开(公告)号:US20180162901A1
公开(公告)日:2018-06-14
申请号:US15891978
申请日:2018-02-08
发明人: David Beebe , Lindsay Strotman , Scott M. Berry
摘要: A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The method includes the steps of capturing the fraction-bound solid phase substrate and bringing an isolation buffer and the fraction-bound solid phase substrate into contact to purify the captured fraction-bound solid phase substrate.
-
公开(公告)号:US09975919B2
公开(公告)日:2018-05-22
申请号:US14766129
申请日:2014-02-05
发明人: Peter Stanley Gagnon
IPC分类号: C07K16/30 , B01D15/36 , B01D15/34 , C07K16/00 , C07K1/20 , C07K1/14 , C07K1/16 , B01D15/32 , B01D15/38
CPC分类号: C07K1/14 , B01D15/327 , B01D15/34 , B01D15/363 , B01D15/3828 , C07K1/165 , C07K1/20 , C07K16/00 , C07K16/3015
摘要: A method of reducing aggregate and product-contaminant complex content in a protein preparation including a desired protein includes (i) contacting the protein preparation with at least one solid surface comprising at least one surface-bound ligand capable of binding a metal, the surface-bound ligand being capable of binding a metal is initially substantially devoid of a metal, the operating conditions are selected to substantially prevent the binding of the desired protein to the at least one solid surface and (ii) separating the protein preparation from the surface-bound ligand, such that when more than one surface-bound ligand is present, each surface-bound ligand is independently either of the same net charge or charge neutral.
-
公开(公告)号:US20180127458A1
公开(公告)日:2018-05-10
申请号:US15732357
申请日:2017-10-30
申请人: Pulse Holdings, LLC
发明人: James A. REHKOPF , David A. MIRKO
IPC分类号: C07K1/14 , C07K14/415 , C07K14/78
CPC分类号: C07K1/14 , C07K14/415 , C07K14/78 , Y10T428/2982
摘要: Methods for pulse combustion spray drying of heat-sensitive protein compositions using high temperature pulsating jets to atomize and dry the feed simultaneously are described herein. Methods and compositions described herein provide dried protein-containing compositions with low protein denaturation and other useful functional properties at high operational efficiencies.
-
公开(公告)号:US20180118782A1
公开(公告)日:2018-05-03
申请号:US15807512
申请日:2017-11-08
申请人: Baxalta Incorporated , Baxalta GmbH
发明人: Leopold Bruckschwaiger , Sonja Svatos , Julia Nuernberger , Wolfgang Teschner , Harald Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
CPC分类号: C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要: The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
-
10.
公开(公告)号:US20180112207A1
公开(公告)日:2018-04-26
申请号:US15543425
申请日:2015-01-15
申请人: SHIMADZU CORPORATION
发明人: Masaki KANAI , Tetsuo OHASHI , Takahiro NISHIMOTO
CPC分类号: C12N15/1013 , B01L3/502 , B01L2200/0631 , B01L2200/0647 , B01L2200/0673 , B01L2300/0832 , B01L2300/0838 , B01L2400/043 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , C07K1/14 , C07K16/00
摘要: A device for manipulating magnetic particles includes a gelled medium layer and liquid layers alternately stacked in a tubular container along a longitudinal direction of the container. A magnetic particle movement portion for moving magnetic particles exists along an inner wall surface of the container, and the magnetic particle movement portion extends along the longitudinal direction of the container. At a portion where the gelled medium layer is loaded, the cross-sectional shape of the container inner wall in a plane perpendicular to the longitudinal direction of the container is non-circular, and the shape of the magnetic particle movement portion in the cross section is a curved shape or an angular shape.
-
-
-
-
-
-
-
-
-