公开(公告)号：US10112990B2

公开(公告)日：2018-10-30

申请号：US15171143

申请日：2016-06-02

Applicant: GENENTECH, INC. ,  AC IMMUNE SA

Inventor： Oskar Adolfsson ,  Gai Ayalon ,  Isidro Hotzel ,  Danielle Marie Di Cara

IPC: C07K16/18 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00 ,  A61K45/00

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US20170320940A1

公开(公告)日：2017-11-09

申请号：US15644007

申请日：2017-07-07

Applicant: Genentech, Inc.

Inventor： Gai Ayalon ,  Till Mauer

IPC: C07K16/18 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K39/3955 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  G01N2800/28 ,  G01N2800/2828 ,  G01N2800/2835

Abstract: The present invention relates to anti-alpha-synuclein (anti-α-synuclein) antibodies and methods of using the same.

公开(公告)号：US09598485B2

公开(公告)日：2017-03-21

申请号：US14773332

申请日：2014-03-12

Applicant: AC IMMUNE S.A. ,  Genentech, Inc.

Inventor： Gai Ayalon ,  Danielle Marie Di Cara ,  Isidro Hotzel ,  Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren ,  Oskar Adolfsson

IPC: C07K16/18 ,  C07K16/44 ,  A61K47/48

CPC classification number: C07K16/18 ,  A61K47/6843 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same.

公开(公告)号：US20150175682A1

公开(公告)日：2015-06-25

申请号：US14390085

申请日：2013-03-15

Applicant: AC Immune S.A. ,  Katholieke Universiteit Leuven ,  Genentech, Inc.

Inventor： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren ,  Oskar Adolfsson ,  Fred Van Leuven ,  Gai Ayalon ,  Danielle Marie Di Cara ,  Isidro Hotzel

IPC: C07K16/18 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/52

Abstract: The present invention provides, methods end composites for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the Invention relates to humanized antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers to methods and compositions involving antibodies for the therapeutic and diagnostic use In the treatment of tauopathies including Alzheimer's Disease (AD).

Abstract translation: 本发明提供了用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结相关的疾病和病症的终端复合材料的方法。 特别地，本发明涉及人源化抗体，其特异性识别并结合磷酸化病理蛋白质tau构象体，涉及用于治疗和诊断用途的抗体的方法和组合物用于治疗包括阿尔茨海默氏病（AD）在内的tau蛋白病。