公开(公告)号：US20190031750A1

公开(公告)日：2019-01-31

申请号：US16033353

申请日：2018-07-12

Applicant: Genentech, Inc.

Inventor： Patrick KOENIG ,  Chingwei Vivian LEE ,  Karthikan RAJAGOPAL ,  Amin FAMILI ,  Germaine FUH

IPC: C07K16/22 ,  A61K47/60 ,  C07K16/46 ,  A61K47/61 ,  C12N15/10 ,  A61K39/395 ,  C12N15/115

Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.