-
公开(公告)号：US20200002411A1
公开(公告)日：2020-01-02
申请号：US16572822
申请日：2019-09-17
Applicant: Genentech, Inc.
Inventor： Amin FAMILI , Germaine FUH , Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL
Abstract: The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).
-
公开(公告)号：US20210363231A1
公开(公告)日：2021-11-25
申请号：US17392943
申请日：2021-08-03
Applicant: Genentech, Inc.
Inventor： Amin FAMILI , Germaine FUH , Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL
Abstract: The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).
-
Patent Agency Ranking
公开(公告)号：US20210115124A1
公开(公告)日：2021-04-22
申请号：US17129251
申请日：2020-12-21
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , A61K47/60 , A61K47/61 , A61K39/395 , A61K47/34 , C07K14/475 , C07K16/44 , C07K16/46 , C12N15/10 , C12N15/115
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
-
公开(公告)号：US20170096479A1
公开(公告)日：2017-04-06
申请号：US15274612
申请日：2016-09-23
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , C07K16/46 , C12N15/10 , C12N15/115 , A61K47/34 , C07K16/44 , A61K39/395 , C07K14/475
CPC classification number: C07K16/22 , A61K39/3955 , A61K47/34 , A61K47/60 , A61K47/61 , A61K2039/505 , A61K2039/54 , C07K14/475 , C07K16/44 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C12N15/1037 , C12N15/115 , C12N2310/16
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
-
公开(公告)号：US20230364020A1
公开(公告)日：2023-11-16
申请号：US18194542
申请日：2023-03-31
Applicant: Genentech, Inc.
Inventor： Purnendu Kumar NAYAK , Debby Pei-Shan CHANG , Karthikan RAJAGOPAL , Jonathan ZARZAR
CPC classification number: A61K9/1652 , A61K9/1617 , A61K9/1623 , A61K9/1647 , C07K16/32 , C07K16/22 , C07K16/4291 , A61K9/1694
Abstract: The present invention provides formulations comprising polypeptides and hydroxypropyl methylcellulose acetate succinate (HPMCAS) derivatives. The formulations are stable; for example, during high temperature processing and in possible low pH environments. In addition, the HPMCAS derivatives provide protection to a pH sensitive protein against acidic degradation products from aqueous hydrolysis of poly(lactic-co-glycolic acid) (PLGA) in PLGA-based delivery systems.
-
公开(公告)号：US20190100581A1
公开(公告)日：2019-04-04
申请号：US16033499
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , C07K16/46 , A61K47/61 , C12N15/10 , C12N15/115 , C07K16/44 , A61K47/34 , A61K47/60 , C07K14/475 , A61K39/395 , A61K39/00
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
-
公开(公告)号：US20190031750A1
公开(公告)日：2019-01-31
申请号：US16033353
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , A61K47/60 , C07K16/46 , A61K47/61 , C12N15/10 , A61K39/395 , C12N15/115
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
-
-
-
-
-
-
Search Results
7
records
(took 0.023 seconds)
