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公开(公告)号:US09738722B2
公开(公告)日:2017-08-22
申请号:US14156432
申请日:2014-01-15
IPC分类号: C07K14/435 , C07K14/705 , C07K14/735 , C07K16/18 , C07K19/00 , A61K38/17 , A61K39/395 , C07K16/28 , C07K16/42 , C07K16/10 , C07K16/46 , A61K39/00
CPC分类号: C07K16/2878 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/1774 , A61K39/395 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K14/435 , C07K16/1027 , C07K16/18 , C07K16/2803 , C07K16/4291 , C07K16/46 , C07K2317/24 , C07K2317/30 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要: The present invention relates to rapid clearance molecules that bind target antigens and FcγRIIb with increased affinity as compared to parent molecules, the compositions being capable of causing accelerated clearance of such antigens. Such compositions are useful for treating a variety of disorders, including allergic diseases, atherosclerosis, and a variety of other conditions.
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公开(公告)号:US20140294759A1
公开(公告)日:2014-10-02
申请号:US14217166
申请日:2014-03-17
摘要: The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells.
摘要翻译: 本发明涉及用于调节T细胞的方法和组合物。 调节包括抑制或诱导调节性T细胞或细胞毒性T细胞。
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公开(公告)号:US20140212436A1
公开(公告)日:2014-07-31
申请号:US14156432
申请日:2014-01-15
IPC分类号: C07K16/18
CPC分类号: C07K16/2878 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/1774 , A61K39/395 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K14/435 , C07K16/1027 , C07K16/18 , C07K16/2803 , C07K16/4291 , C07K16/46 , C07K2317/24 , C07K2317/30 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要: The present invention relates to rapid clearance molecules that bind target antigens and FcγRIIb with increased affinity as compared to parent molecules, said compositions being capable of causing accelerated clearance of such antigens. Such compositions are useful for treating a variety of disorders, including allergic diseases, atherosclerosis, and a variety of other conditions.
摘要翻译: 本发明涉及与亲本分子相比具有增加的亲和力的结合靶抗原的快速清除分子和FcγRIIb,所述组合物能够促进这些抗原的加速清除。 这样的组合物可用于治疗各种疾病,包括过敏性疾病,动脉粥样硬化和各种其他病症。
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