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公开(公告)号:US20140294759A1
公开(公告)日:2014-10-02
申请号:US14217166
申请日:2014-03-17
摘要: The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells.
摘要翻译: 本发明涉及用于调节T细胞的方法和组合物。 调节包括抑制或诱导调节性T细胞或细胞毒性T细胞。
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公开(公告)号:US20170037131A1
公开(公告)日:2017-02-09
申请号:US15063441
申请日:2016-03-07
IPC分类号: C07K16/28
CPC分类号: C07K16/2812 , A61K2039/505 , C07K16/2818 , C07K16/2866 , C07K2317/30 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要: The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells.
摘要翻译: 本发明涉及用于调节T细胞的方法和组合物。 调节包括抑制或诱导调节性T细胞或细胞毒性T细胞。
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公开(公告)号:US20150307629A1
公开(公告)日:2015-10-29
申请号:US14673695
申请日:2015-03-30
申请人: Matthew Bernett , Seung Chu , Gregory Moore , John Desjarlais
发明人: Matthew Bernett , Seung Chu , Gregory Moore , John Desjarlais
CPC分类号: C07K16/468 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要: The invention provides novel heterodimeric proteins including heterodimeric antibodies.
摘要翻译: 本发明提供了包括异二聚体抗体的新型异二聚体蛋白。
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公开(公告)号:US20070148171A1
公开(公告)日:2007-06-28
申请号:US11544165
申请日:2006-10-06
申请人: Gregory Lazar , John Desjarlais , Philip Hammond , David Carmichael , Bao-lu Chen , Seung Chu , Sher Karki
发明人: Gregory Lazar , John Desjarlais , Philip Hammond , David Carmichael , Bao-lu Chen , Seung Chu , Sher Karki
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/2878 , A61K39/39591 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要: An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.
摘要翻译: 靶向CD30的抗体,其中所述抗体相对于亲本抗体包含至少一个修饰,并且与亲本抗体相比,抗体以对FcγRR的改变的亲和力结合或改变效应子功能。 还公开了使用抗CD30抗体的方法。
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公开(公告)号:US20050130892A1
公开(公告)日:2005-06-16
申请号:US10944473
申请日:2004-09-16
申请人: John Desjarlais , Adam Thomason , Eugene Zhukovsky , Seung Chu
发明人: John Desjarlais , Adam Thomason , Eugene Zhukovsky , Seung Chu
IPC分类号: A61K38/00 , C07K14/525 , C07K14/705 , A61K38/18 , C07K14/475
CPC分类号: C07K14/70575 , A61K38/00 , C07K14/525 , C07K2319/00 , C07K2319/43
摘要: The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or APRIL-related disorders.
摘要翻译: 本发明涉及具有BAFF显性负性拮抗剂的新型蛋白质,受体拮抗剂活性和激动剂活性以及编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗BAFF或APRIL相关疾病中的用途。
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公开(公告)号:US20070166309A1
公开(公告)日:2007-07-19
申请号:US11686853
申请日:2007-03-15
申请人: Gregory Lazar , John Desjarlais , Philip Hammond , David Carmichael , Bao-lu Chen , Seung Chu , Sher Karki
发明人: Gregory Lazar , John Desjarlais , Philip Hammond , David Carmichael , Bao-lu Chen , Seung Chu , Sher Karki
IPC分类号: A61K39/395 , C07K16/30
CPC分类号: C07K16/2878 , A61K39/39591 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要: An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.
摘要翻译: 靶向CD30的抗体,其中所述抗体相对于亲本抗体包含至少一个修饰,并且与亲本抗体相比,抗体以对FcγRR的改变的亲和力结合或改变效应子功能。 还公开了使用抗CD30抗体的方法。
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