公开(公告)号：US09993477B2

公开(公告)日：2018-06-12

申请号：US15452827

申请日：2017-03-08

Applicant: H. LUNDBECK A/S

Inventor： Niels Svenstrup ,  Klaus Bæk Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

IPC: A61K31/4985 ,  C07D487/04 ,  A61K31/506

CPC classification number: A61K31/506 ,  C07D487/04

Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I) The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

公开(公告)号：US09850249B2

公开(公告)日：2017-12-26

申请号：US15358168

申请日：2016-11-22

Applicant: H. Lundbeck A/S

Inventor： Niels Svenstrup ,  Klaus Bæk Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

IPC: C07D487/04 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

公开(公告)号：US20170173018A1

公开(公告)日：2017-06-22

申请号：US15452827

申请日：2017-03-08

Applicant: H. LUNDBECK A/S

Inventor： Niels Svenstrup ,  Klaus Bæk Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

IPC: A61K31/506

CPC classification number: A61K31/506 ,  C07D487/04

Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I) The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

公开(公告)号：US09643970B2

公开(公告)日：2017-05-09

申请号：US14434308

申请日：2012-10-09

Applicant: H Lundbeck A/S

Inventor： Niels Svenstrup ,  Klaus Baek Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgard ,  Kate Wen ,  Yazhou Wang

IPC: A61K31/4985 ,  C07D487/04

CPC classification number: A61K31/506 ,  C07D487/04

Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I) The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).