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    PDE9 Inhibitors with Imidazo Triazinone Backbone
    1.
    发明申请
    PDE9 Inhibitors with Imidazo Triazinone Backbone 有权

    公开(公告)号：US20170081333A1

    公开(公告)日：2017-03-23

    申请号：US15358168

    申请日：2016-11-22

    Applicant: H. Lundbeck A/S

    Inventor： Niels Svenstrup ,  Klaus Baiek Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

    IPC: C07D487/04

    CPC classification number: C07D487/04 ,  A61K31/53

    Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

    PDE9 inhibitors with imidazo triazinone backbone
    3.
    发明授权
    PDE9 inhibitors with imidazo triazinone backbone 有权

    公开(公告)号：US09434733B2

    公开(公告)日：2016-09-06

    申请号：US14374278

    申请日：2013-01-25

    Applicant: H. Lundbeck A/S

    Inventor： Niels Svenstrup ,  Klaus Bæk Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

    IPC: C07D487/04

    CPC classification number: C07D487/04 ,  A61K31/53

    Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

    PDE9i with imidazo pyrazinone backbone
    4.
    发明申请
    PDE9i with imidazo pyrazinone backbone 有权
    PDE9i与咪唑并吡嗪酮骨架

    公开(公告)号：US20150274736A1

    公开(公告)日：2015-10-01

    申请号：US14434308

    申请日：2012-10-09

    Applicant: H. LUNDBECK A/S

    Inventor： Niels Svenstrup ,  Klaus Baek Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgard ,  Kate Wen ,  Yazhou Wang

    IPC: C07D487/04

    CPC classification number: A61K31/506 ,  C07D487/04

    Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

    Abstract translation: 本发明涉及PDE9酶抑制剂的化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供制备式（I）化合物的方法。 本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括给予受试者治疗有效量的式（I）化合物。 本发明还提供了治疗患有精神障碍的受试者的方法，其包括向受试者施用治疗有效量的式（I）化合物。

    PDE9 inhibitors with imidazo triazinone backbone
    7.
    发明授权
    PDE9 inhibitors with imidazo triazinone backbone 有权
    PDE9抑制剂与咪唑并三酮骨架

    公开(公告)号：US09533992B2

    公开(公告)日：2017-01-03

    申请号：US15089819

    申请日：2016-04-04

    Applicant: H. Lundbeck A/S

    Inventor： Niels Svenstrup ,  Klaus Bæk Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

    IPC: C07D487/04 ,  A61K31/53

    CPC classification number: C07D487/04 ,  A61K31/53

    Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a compound of formula (I) for use in a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

    Abstract translation: 本发明涉及PDE9酶抑制剂的化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供制备式（I）化合物的方法。 本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括给予受试者治疗有效量的式（I）化合物。 本发明还提供用于治疗患有精神障碍的受试者的方法的式（I）化合物，其包括向受试者施用治疗有效量的式（I）化合物。

    PDE9 Inhibitors with Imidazo Triazinone Backbone
    8.
    发明申请
    PDE9 Inhibitors with Imidazo Triazinone Backbone 有权
    PDE9抑制剂与咪唑三嗪酮骨干

    公开(公告)号：US20160213674A1

    公开(公告)日：2016-07-28

    申请号：US15089819

    申请日：2016-04-04

    Applicant: H. Lundbeck A/S

    Inventor： Niels Svenstrup ,  Klaus Bæk Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

    IPC: A61K31/53

    CPC classification number: C07D487/04 ,  A61K31/53

    Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a compound of formula (I) for use in a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

    Abstract translation: 本发明涉及PDE9酶抑制剂的化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供制备式（I）化合物的方法。 本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括给予受试者治疗有效量的式（I）化合物。 本发明还提供用于治疗患有精神障碍的受试者的方法的式（I）化合物，其包括向受试者施用治疗有效量的式（I）化合物。

    PDE9 inhibitors with imidazo triazinone backbone
    9.
    发明申请
    PDE9 inhibitors with imidazo triazinone backbone 有权
    PDE9抑制剂与咪唑并三酮骨架

    公开(公告)号：US20150045348A1

    公开(公告)日：2015-02-12

    申请号：US14374278

    申请日：2013-01-25

    Applicant: H. Lundbeck A/S

    Inventor： Niels Svenstrup ,  Klaus Bæk Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgärd ,  Kate Wen ,  Yazhou Wang

    IPC: C07D487/04

    CPC classification number: C07D487/04 ,  A61K31/53

    Abstract: This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

    Abstract translation: 本发明涉及PDE9酶抑制剂的化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供制备式（I）化合物的方法。 本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括给予受试者治疗有效量的式（I）化合物。 本发明还提供了治疗患有精神障碍的受试者的方法，其包括向受试者施用治疗有效量的式（I）化合物。

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