公开(公告)号：US3660422A

公开(公告)日：1972-05-02

申请号：US3660422D

申请日：1969-07-11

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  DURCKHEIMER WALTER ,  DUWEL DIETER

IPC: C07D235/24 ,  C07C333/24 ,  C07D235/06 ,  C07D49/38

CPC classification number: C07D235/06 ,  Y10S514/893

Abstract: WHEREIN X IS CHLORINE, BROMINE, OR IODINE.

R3-CH(-X)-R4

WHEREIN R1 AND R2 ARE HYDROGEN, HALOGEN, ALKYL HAVING 1-6 CARBON ATOMS, OR ALKOXY HAVING 1-6 CARBON ATOMS, R3 IS HYDROGEN OR ALKYL HAVING 1-6 CARBON ATOMS, AND R4 IS 2-BENZIMIDAZOLE OR 2-BENZAMIDAZOLE SUBSTITUTED WITH ONE OR MORE HALOGEN, LOWER ALKYL, TRIFLUOROMETHYL, LOWER ALKOXY, NITRO, SULFAMIDO, OR NITRILO GROUPS. THE ESTERS, WHICH ARE ACTIVE AGAINST LIVER FLUKES FOR EXAMPLE, ARE PREPARED BY REACTING A SALT OF A CORRESPONDING BIS-DITHIOCARBAMIC ACID WITH A COMPOUND OF THE FORMULA
ANTHELMINTICALLY-ACTIVE BIS-DITHIOCARBAMIC ESTERS OF THE FORMULA

1-R1,2,5-BIS(R3-CH(-R4)-S-C(=S)-NH-),4-R2-BENZENE