公开(公告)号：US4054568A

公开(公告)日：1977-10-18

申请号：US661455

申请日：1976-02-25

申请人： Hideo Agui ,  Toru Mitani ,  Mitsuo Nakashita ,  Eiichi Murayama ,  Kousaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

发明人： Hideo Agui ,  Toru Mitani ,  Mitsuo Nakashita ,  Eiichi Murayama ,  Kousaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

IPC分类号： C07D513/04

CPC分类号： C07D513/04

摘要： Thiazolo[5,4-f]quinoline-8-carboxylic acid derivatives having either the general formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group, a lower alkenyl group or a benzyl group; or the general formula (III-a): ##STR2## WHEREIN R.sub.3 is a lower alkyl group and X is a halogen atom; and methods for the preparation thereof. The compounds of the general formula (I) are useful as antibacterial agents against gram-negative and gram-positive bacteria. The compounds of the general formula (III-a) are useful as antifungal agents against eumycetes and also as an intermediate in a peparation of the compounds of the general formula (I).

摘要翻译： 具有通式（I）的噻唑并[5,4-f]喹啉-8-羧酸衍生物：其中R1是低级烷基，低级烯基或苄基; （III-a）：（III-a）其中R3为低级烷基，X为卤素原子; 及其制备方法。 通式（I）的化合物可用作抗革兰氏阴性细菌和革兰氏阳性细菌的抗菌剂。 通式（III-a）的化合物可用作抗真菌剂的抗真菌剂，也可用作通式（I）化合物的分离中的中间体。

公开(公告)号：US3951955A

公开(公告)日：1976-04-20

申请号：US491693

申请日：1974-07-25

申请人： Hisao Tobiki ,  Kozo Shimago ,  Shigeru Okano ,  Toshiaki Komatsu ,  Toyozo Katsura ,  Yasushi Taira ,  Yasuko Eda

发明人： Hisao Tobiki ,  Kozo Shimago ,  Shigeru Okano ,  Toshiaki Komatsu ,  Toyozo Katsura ,  Yasushi Taira ,  Yasuko Eda

IPC分类号： C07D499/00 ,  C07D499/64 ,  C07D499/44

CPC分类号： C07D499/00

摘要： A penicillin of the formula: ##SPC1##Wherein A is a substituted or unsubstituted condensed aromatic carbocyclic or heterocyclic ring, R is hydrogen or lower alkyl, X is oxygen or sulfur, Y is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl and Z is phenyl or thienyl which can be produced by reacting 6-aminopenicillanic acid or its ester with a carboxylic acid of the formula: ##SPC2##Wherein A, R, X, Y and Z are each as defined above or its reactive derivative. The said penicillin and its non-toxic salts have a broad antimicrobial spectrum against various gram-positive and gram-negative bacteria, and they exhibit characteristically a strong antimicrobial activity against Pseudomonas.

摘要翻译： 青霉素的配方：

公开(公告)号：US4008237A

公开(公告)日：1977-02-15

申请号：US626001

申请日：1975-10-28

申请人： Hideo Agui ,  Iwao Nakatsuka ,  Toru Mitani ,  Mitsuo Nakashita ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

发明人： Hideo Agui ,  Iwao Nakatsuka ,  Toru Mitani ,  Mitsuo Nakashita ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

IPC分类号： C07D215/56 ,  C07D491/048

CPC分类号： C07D491/048

摘要： Novel antibacterial agents consisting of a 2,3,5,8-tetrahydro-5-alkoxy-8-oxofuro(2,3-g)quinoline-7-carboxylic acid of the formula: ##STR1## wherein R is C.sub.1 -C.sub.4 alkyl, a process for producing the derivatives and pharmaceutical compositions containing the same. The above-identified derivatives possess antibacterial activity against gram-negative bacteria at test concentration levels of about 0.0001 to 1.0 mg/cc.

摘要翻译： 新型抗菌剂由下列通式的2,3,5,8-四氢-5-烷氧基-8-氧代呋喃（2,3-g）喹啉-7-羧酸组成，其中R是C 1 -C 4烷基 ，制备衍生物的方法和含有该衍生物的药物组合物。 上述衍生物在约0.0001至1.0mg / cc的测试浓度水平下对革兰氏阴性细菌具有抗菌活性。