中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

29 records (took 0.017 seconds)

    DUAL SPECIFICITY POLYPEPTIDE MOLECULE
    15.
    发明申请
    DUAL SPECIFICITY POLYPEPTIDE MOLECULE 审中-公开

    公开(公告)号：US20190016804A1

    公开(公告)日：2019-01-17

    申请号：US16035429

    申请日：2018-07-13

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Martin HOFMANN ,  Felix UNVERDORBEN ,  Sebastian BUNK ,  Dominik MAURER

    IPC: C07K16/28 ,  C07K16/10

    Abstract: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated viral peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.

    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING PRAME
    19.
    发明申请
    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING PRAME 有权

    公开(公告)号：US20230091330A1

    公开(公告)日：2023-03-23

    申请号：US17934303

    申请日：2022-09-22

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Gabriele PSZOLLA ,  Martin HOFMANN ,  Meike HUTT ,  Sebastian BUNK ,  Felix UNVERDORBEN ,  Frank SCHWOEBEL ,  Dominik MAURER ,  Maike JAWORSKI ,  Claudia WAGNER ,  Florian SCHWOERER ,  Heiko SCHUSTER

    IPC: C07K16/30 ,  C07K16/28 ,  C07K16/46

    Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING CT45
    20.
    发明申请
    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING CT45 有权

    公开(公告)号：US20230057987A1

    公开(公告)日：2023-02-23

    申请号：US17874711

    申请日：2022-07-27

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Sara YOUSEF ,  Fabian BRUNK ,  Andreas MORITZ ,  Sebastian BUNK ,  Claudia WAGNER ,  Dominik MAURER ,  Felix UNVERDORBEN

    IPC: C07K16/30 ,  C07K14/725 ,  G01N33/574

    Abstract: The present invention provides an antigen binding protein specifically binding to a CT45 antigenic peptide that is in a complex with a major histocompatibility complex (MHC) protein, wherein the CT45 antigenic peptide comprises or consists of the amino acid sequence of SEQ ID NO: 138 (KIFEMLEGV) and wherein the antigen binding protein comprises a first polypeptide comprising a variable domain VA comprising complementarity determining regions CDRa1, CDRa2 and CDRa3 and a second polypeptide comprising a variable domain VB comprising CDRb1, CDRb2 and CDRb3. Also provided are nucleic acids encoding the antigen binding proteins, vectors comprising the nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins. The invention further provides the antigen binding proteins for use in medicine and a method of producing the antigen binding protein.

Patent Agency Ranking