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    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING CT45
    1.
    发明申请
    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING CT45 有权

    公开(公告)号：US20250122302A1

    公开(公告)日：2025-04-17

    申请号：US18989486

    申请日：2024-12-20

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Sara YOUSEF ,  Fabian BRUNK ,  Andreas MORITZ ,  Sebastian BUNK ,  Claudia WAGNER ,  Dominik MAURER ,  Felix UNVERDORBEN

    IPC: C07K16/30 ,  C07K14/725 ,  G01N33/574

    Abstract: The present invention provides an antigen binding protein specifically binding to a CT45 antigenic peptide that is in a complex with a major histocompatibility complex (MHC) protein, wherein the CT45 antigenic peptide comprises or consists of the amino acid sequence of SEQ ID NO: 138 (KIFEMLEGV) and wherein the antigen binding protein comprises a first polypeptide comprising a variable domain VA comprising complementarity determining regions CDRa1, CDRa2 and CDRa3 and a second polypeptide comprising a variable domain VB comprising CDRb1, CDRb2 and CDRb3. Also provided are nucleic acids encoding the antigen binding proteins, vectors comprising the nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins. The invention further provides the antigen binding proteins for use in medicine and a method of producing the antigen binding protein.

    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING MAGE-A
    5.
    发明申请
    ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING MAGE-A 有权

    公开(公告)号：US20210032361A1

    公开(公告)日：2021-02-04

    申请号：US16943779

    申请日：2020-07-30

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Meike HUTT ,  Felix UNVERDORBEN ,  Sebastian BUNK ,  Dominik MAURER ,  Martin HOFMANN ,  Gabriele PSZOLLA ,  Sara YOUSEF ,  Claudia WAGNER ,  Frank SCHWOEBEL ,  Heiko SCHUSTER

    IPC: C07K16/30 ,  C07K14/725 ,  A61P35/00

    Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

    DUAL SPECIFICITY POLYPEPTIDE MOLECULE
    9.
    发明申请
    DUAL SPECIFICITY POLYPEPTIDE MOLECULE 审中-公开

    公开(公告)号：US20190016801A1

    公开(公告)日：2019-01-17

    申请号：US16035403

    申请日：2018-07-13

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Martin HOFMANN ,  Felix UNVERDORBEN ,  Sebastian BUNK ,  Dominik MAURER

    IPC: C07K16/28 ,  C07K16/10 ,  C07K16/30

    Abstract: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.

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