公开(公告)号：US20190218308A1

公开(公告)日：2019-07-18

申请号：US16370726

申请日：2019-03-29

Applicant: INNATE PHARMA

Inventor： Stéphanie Chanteux ,  Nicolas Gourdin ,  Carine Paturel ,  Ivan Perrot ,  Benjamin Rossi

IPC: C07K16/40 ,  A61P35/00 ,  G01N33/574 ,  C07K16/28 ,  A61K9/00

CPC classification number: C07K16/2896 ,  A61K39/001154 ,  A61K2039/507 ,  A61K2039/545 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/92 ,  C12N9/14

Abstract: The present invention relates to methods of using compounds that inhibit the enzymatic activity of soluble human CD39 to treat cancer, including but not limited to the treatment of cancers characterized by CD73 expressing cells.

公开(公告)号：US20230340143A1

公开(公告)日：2023-10-26

申请号：US18168522

申请日：2023-02-13

Applicant: Innate Pharma ,  OREGA BIOTECH

Inventor： Stéphanie Chanteux ,  Nicolas Gourdin ,  Carine Paturel ,  Ivan Perrot ,  Benjamin Rossi

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574 ,  A61P35/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  G01N33/57492 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to antigen-binding compounds that inhibit the enzymatic activity of soluble human CD39. The invention also relates to cells producing such compounds; methods of making such compounds, and antibodies, fragments, variants, and derivatives thereof; pharmaceutical compositions comprising the same; methods of using the compounds to diagnose, treat or prevent diseases, e.g., cancer.

公开(公告)号：US11130817B2

公开(公告)日：2021-09-28

申请号：US15767661

申请日：2016-10-11

Applicant: INNATE PHARMA ,  CENTRE LEON BERARD

Inventor： Christophe Caux ,  Laurent Gauthier ,  Nicolas Gourdin ,  Christine Menetrier-Caux ,  Carine Paturel ,  Ivan Perrot

IPC: C07K16/28 ,  C07K16/40 ,  A61P35/00

Abstract: Provided are antibodies that bind and inhibit CD73, are capable of increasing the proliferation of T cells in the presence of CD39-expressing B cells and ATP. The invention also relates to cells producing such compounds; methods of making such compounds, and antibodies, fragments, variants, and derivatives thereof; pharmaceutical compositions comprising the same; methods of using the compounds to diagnose, treat or prevent cancer.

公开(公告)号：US20190389961A1

公开(公告)日：2019-12-26

申请号：US16477506

申请日：2018-03-16

Applicant: Innate Pharma

Inventor： Stéphanie Chanteux ,  Nicolas Gourdin ,  Carine Paturel ,  Ivan Perrot ,  Benjamin Rossi

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574

Abstract: The present invention relates to antigen-binding compounds that inhibit the enzymatic activity of soluble human CD39. The invention also relates to cells producing such compounds; methods of making such compounds, and antibodies, fragments, variants, and derivatives thereof; pharmaceutical compositions comprising the same; methods of using the compounds to diagnose, treat or prevent diseases, e.g., cancer.

公开(公告)号：US20150191542A1

公开(公告)日：2015-07-09

申请号：US14377274

申请日：2013-02-07

Applicant: INNATE PHARMA, S.A.

Inventor： Mathieu Blery ,  Laurent Gauthier ,  Ivan Perrot ,  Cecile Bonnafous

IPC: C07K16/28 ,  G01N33/569

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2833 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56977 ,  G01N2333/70539

Abstract: The present invention relates to methods for the treatment of disorders mediated by MICA-expressing cells using antibodies, antibody fragments, and derivatives thereof that specifically bind MICA. The invention also relates to antibodies; cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; and pharmaceutical compositions comprising the same.

Abstract translation: 本发明涉及使用特异性结合MICA的抗体，抗体片段及其衍生物治疗由MICA表达细胞介导的病症的方法。 本发明还涉及抗体; 产生这种抗体的细胞; 制备此类抗体的方法; 抗体的片段，变体和衍生物; 和包含其的药物组合物。

公开(公告)号：US20150140000A1

公开(公告)日：2015-05-21

申请号：US14403171

申请日：2013-05-30

Applicant: INNATE PHARMA

Inventor： Cécile Bonnafous ,  Laurent Gauthier ,  Yannis Morel ,  Carine Paturel ,  Ivan Perrot

IPC: C07K16/28 ,  A61K47/48

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Disclosed herein are anti-TLR3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-TLR3 antibodies.

Abstract translation: 本文公开了抗TLR3抗体以及制备和使用它们的方法。 抗体特别适用于使用抗TLR3抗体治疗自身免疫性或炎性疾病。