公开(公告)号：US10577416B2

公开(公告)日：2020-03-03

申请号：US14377274

申请日：2013-02-07

Applicant: INNATE PHARMA, S.A.

Inventor： Mathieu Blery ,  Laurent Gauthier ,  Ivan Perrot ,  Cecile Bonnafous

IPC: C07K16/28 ,  A61K39/00 ,  G01N33/569

Abstract: The present invention relates to methods for the treatment of disorders mediated by MICA-expressing cells using antibodies, antibody fragments, and derivatives thereof that specifically bind MICA. The invention also relates to antibodies; cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; and pharmaceutical compositions comprising the same.

公开(公告)号：US20150191542A1

公开(公告)日：2015-07-09

申请号：US14377274

申请日：2013-02-07

Applicant: INNATE PHARMA, S.A.

Inventor： Mathieu Blery ,  Laurent Gauthier ,  Ivan Perrot ,  Cecile Bonnafous

IPC: C07K16/28 ,  G01N33/569

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2833 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56977 ,  G01N2333/70539

Abstract: The present invention relates to methods for the treatment of disorders mediated by MICA-expressing cells using antibodies, antibody fragments, and derivatives thereof that specifically bind MICA. The invention also relates to antibodies; cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; and pharmaceutical compositions comprising the same.

Abstract translation: 本发明涉及使用特异性结合MICA的抗体，抗体片段及其衍生物治疗由MICA表达细胞介导的病症的方法。 本发明还涉及抗体; 产生这种抗体的细胞; 制备此类抗体的方法; 抗体的片段，变体和衍生物; 和包含其的药物组合物。