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公开(公告)号：US20210259590A1
公开(公告)日：2021-08-26
申请号：US16796575
申请日：2020-02-20
Applicant: Insulet Corporation
Inventor： Thomas METZMAKER , Nicholas CONTE , Ian MCLAUGHLIN , Joon Bok LEE , Paul Frederick BENTE , Ashutosh ZADE , Steven CARDINALI
Abstract: Disclosed are examples that include receiving information related to ingestion of a meal. The information may include a coarse indication of a size of the meal, a relative time of ingestion of the meal, and a general composition indication of the meal. A blood glucose measurement value received within a predetermined time range of a relative time of ingestion of the meal may be identified. Settings for a delay and an extend parameter and a delivery constraint may be determined. A meal model may be modified using the determined settings for the delay parameter, the extend parameter, and the delivery constraint. The modified meal model may be used to determine a dose of insulin to be delivered in response to the received information. An instruction indicates a determined dose of insulin to be delivered may be output for delivery to a drug delivery device.
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公开(公告)号：US20210077719A1
公开(公告)日：2021-03-18
申请号：US16570125
申请日：2019-09-13
Applicant: Insulet Corporation
Inventor： Steven CARDINALI , Joon Bok LEE , Jason O'CONNOR , Yibin ZHENG
Abstract: Disclosed are a system, methods and computer-readable medium products that provide bolus dosage calculations by a control algorithm-based drug delivery system that provides automatic delivery of a drug, such as insulin or the like, based on sensor input. Blood glucose measurement values may be received at regular time intervals from a sensor. Using the blood glucose measurements, the control algorithm may perform various calculations and determinations to provide an appropriate bolus dosage. The appropriate bolus dosage may be used to respond to a trend in a trajectory of blood glucose measurements. In addition, a bolus dosage may also be determined by the disclosed device, system, method and/or computer-readable medium product in response to an indication that a user consumed a meal.
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公开(公告)号：US20210016015A1
公开(公告)日：2021-01-21
申请号：US17039570
申请日：2020-09-30
Applicant: Insulet Corporation
Inventor： Steven CARDINALI , David NAZZARO , Daniel ALLIS , Maureen MCCAFFREY
IPC: A61M5/315
Abstract: Drive systems for a drug delivery device are provided. The drive systems can be positioned within a container that stores a liquid drug to be delivered to a user. The drive systems can be coupled to a plunger positioned within the container. The drive systems can be incrementally advanced to drive the plunger further into the container, thereby expelling a portion of the stored liquid drug from the container for delivery to the user. The container can be any type of container including a pre-filled, standardized drug cartridge. The drive systems and container can be components of a wearable drug delivery device.
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公开(公告)号：US20230136536A1
公开(公告)日：2023-05-04
申请号：US18052287
申请日：2022-11-03
Applicant: INSULET CORPORATION
Inventor： Steven CARDINALI , Kyle BREINGAN
Abstract: Fluid delivery devices with sterilization management systems are described. For example, a fluid delivery device may include a device region fluidically coupled to a fluid path, the fluid path having at least one opening to allow a sterilization source to flow into the device region, an exposure valve arranged in the fluid path and configured to seal or unseal the at least one opening, the exposure valve comprising a piston having a sealing component arranged at a first end facing the at least one opening, a biasing element configured to contact a second end of the piston, arranged opposite the first end, to bias the piston toward the at least one opening, an activation element configured to be activated by a stimulus to move the piston to a sterilization position during a sterilization process and deactivated responsive to removal of the stimulus to cause the piston to be moved into a sealing position, the at least one opening is unsealed when the piston is in the sterilization position to allow a sterilization source to sterilize the device region via the fluid path. Other embodiments are described.
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公开(公告)号：US20230117504A1
公开(公告)日：2023-04-20
申请号：US18047068
申请日：2022-10-17
Applicant: INSULET CORPORATION
Inventor： Soroush KAMRAVA , Steven CARDINALI , Jeffrey BARNES
Abstract: A novel embodiment of a drive mechanism for use in a pump, for example, of the type that would be used in a wearable drug delivery system, comprises, a cylindrically-shaped slider element configured with a channel on a circumferential surface thereof defining one or more zig-zag-shaped tracks therethrough. One or more pegs are engaged within the tracks, such that a back and forth longitudinal motion of the slider element along a radial axis of the cylinder causes movement of the pegs along one of the tracks through the channel, thus providing a movement of the pegs around the circumference of the cylinder which imparts a rotational motion to a header element disposed co-axially with the slider. The header element is in turn connected to a gear train, for example, a planetary gear box, which is coupled to the pump via a linkage or other type of mechanism.
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Patent Agency Ranking
公开(公告)号：US20220370709A1
公开(公告)日：2022-11-24
申请号：US17749463
申请日：2022-05-20
Applicant: Insulet Corporation
Inventor： Steven CARDINALI
IPC: A61M5/142
Abstract: Embodiments of the present disclosure relate to techniques, processes, devices or systems for pump devices. In one approach, a wearable drug delivery device may include a reservoir configured to store a liquid drug, the reservoir including a housing including an outer wall defining an interior chamber, a sealing member, and a slit through the housing, wherein the sealing member is configured to seal the slit. The wearable drug delivery device may further include a delivery pump device including a drive mechanism coupled to the reservoir for driving the liquid drug out of the reservoir, the drive mechanism including a piston head disposed within the interior chamber of the housing, and a lead screw coupled to a drive nut, wherein the drive nut comprises a blade adjacent the piston head, and wherein the blade is positionable through the slit of the housing.
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公开(公告)号：US20220105267A1
公开(公告)日：2022-04-07
申请号：US17492103
申请日：2021-10-01
Applicant: Insulet Corporation
Inventor： Steven CARDINALI , David NAZZARO , Ian MCLAUGHLIN
Abstract: Methods and apparatuses for performing an insertion process for a plurality of penetrating elements are described. For example, a wearable fluid infusion device may include a cannula and/or needle for infusing a fluid into a patient and a sensor for sensing a physical characteristic of the patient. A non-limiting example of a fluid may be or may include insulin. An illustrative and non-restrictive example of a physical characteristic may include a blood glucose level. The wearable infusion device may be configured to facilitate insertion of the multiple penetrating elements, such as a cannula and a sensor, in a single simultaneous insertion step instead of requiring individual insertion steps for each of multiple penetrating elements. Other embodiments are described.
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公开(公告)号：US20220088303A1
公开(公告)日：2022-03-24
申请号：US17027191
申请日：2020-09-21
Applicant: Insulet Corporation
Inventor： Joon Bok LEE , Yibin ZHENG , Steven CARDINALI , Jason O'CONNOR
Abstract: Methods and apparatuses for performing an insulin infusion process are described. For example, an apparatus may include at least one memory and logic coupled to the at least one memory. The logic may operate to determine a basal parameter for a patient based on a type 2 diabetes (T2D) multiple daily injection (MDI) information of the patient, the basal parameter indicating a basal infusion rate, determine an additional insulin (Iadd) value based on a mean blood glucose difference (BGdiff) information associated with the patient, determine an insulin volume to infuse into the patient based on the basal parameter and Iadd, and administer the insulin volume to the patient. Other embodiments are described.
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公开(公告)号：US20210369981A1
公开(公告)日：2021-12-02
申请号：US17398584
申请日：2021-08-10
Applicant: Insulet Corporation
Inventor： Steven CARDINALI , David NAZZARO , Lawrence S. RING
Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient or user is provided. A soft needle or cannula can be placed in fluid communication with the liquid drug and can be coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the container to the patient through the soft needle or cannula. The wearable drug delivery device can include components for preventing backflow and eliminating air within the liquid drug. As a result, the comfort of the patient can be enhanced and correct drug dosages can be provided when using the drug delivery device.
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公开(公告)号：US20210236730A1
公开(公告)日：2021-08-05
申请号：US17166072
申请日：2021-02-03
Applicant: Insulet Corporation
Inventor： Joon Bok LEE , Ashutosh ZADE , Jason O'CONNOR , Yibin ZHENG , Steven CARDINALI
Abstract: In an automated insulin delivery device, fuzzy logic may be applied to the responding to the possibility of a user taking additional action that may affect the blood glucose concentration. Fuzzy sets may be defined for empirically derived different likelihoods of the user taking such additional action based on correlated factors. A membership function may be provided for each fuzzy set. The membership function may provide a probability of membership in the set based on a parameter. Each fuzzy set may have a response that is reflective of the likelihood of additional user action associated with the fuzzy set. The responses by the AID device to each of these cases may reflect the probability of each such case occurring as evidenced by empirical data.
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