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11.发明授权公开(公告)号：US11433099B2
公开(公告)日：2022-09-06
申请号：US17484452
申请日：2021-09-24
发明人： Gisela Schimmack , Annika Sonntag , Heiko Schuster , Daniel Johannes Kowalewski , Michael Roemer , Jens Fritsche , Oliver Schoor , Toni Weinschenk , Harpreet Singh
IPC分类号： A61K35/17 , A61K39/00 , C07K14/73 , C07K14/705 , C07K14/74
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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12.发明授权公开(公告)号：US10899813B2
公开(公告)日：2021-01-26
申请号：US16917141
申请日：2020-06-30
发明人： Heiko Schuster , Annika Sonntag , Daniel Johannes Kowalewski , Oliver Schoor , Jens Fritsche , Toni Weinschenk , Harpreet Singh , Colette Song
IPC分类号： A61K35/17 , C07K14/47 , C07K14/725 , C07K14/74 , A61K38/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10464991B2
公开(公告)日：2019-11-05
申请号：US15848523
申请日：2017-12-20
发明人： Annika Sonntag , Toni Weinschenk , Andrea Mahr , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： C07K14/74 , G16B25/00 , A61K35/17 , A61K39/00 , C07K14/725 , C07K16/28 , C12N5/0783 , C12N15/115 , C12Q1/6886 , G01N33/574 , A61K38/04 , A61P37/04 , A61P35/00 , A61K38/17 , C07K7/06
摘要： A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has melanoma. A method of treating a patient who has melanoma includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the melanoma.
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公开(公告)号：US10385110B2
公开(公告)日：2019-08-20
申请号：US16165116
申请日：2018-10-19
发明人： Annika Sonntag , Toni Weinschenk , Andrea Mahr , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： C07K14/74 , G16B25/00 , A61K35/17 , A61K39/00 , C07K14/725 , C07K16/28 , C12N5/0783 , C12N15/115 , C12Q1/6886 , G01N33/574 , A61K38/04 , A61P37/04 , A61P35/00 , A61K38/17 , C07K7/06
摘要： A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has melanoma. A method of treating a patient who has melanoma includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the melanoma.
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15.发明授权公开(公告)号：US11142556B2
公开(公告)日：2021-10-12
申请号：US17229592
申请日：2021-04-13
发明人： Heiko Schuster , Annika Sonntag , Daniel Johannes Kowalewski , Oliver Schoor , Jens Fritsche , Toni Weinschenk , Harpreet Singh , Colette Song
IPC分类号： A61K38/00 , C07K14/47 , C07K14/725 , C07K14/74
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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16.发明授权公开(公告)号：US11001617B2
公开(公告)日：2021-05-11
申请号：US16917176
申请日：2020-06-30
发明人： Heiko Schuster , Annika Sonntag , Daniel Johannes Kowalewski , Oliver Schoor , Jens Fritsche , Toni Weinschenk , Harpreet Singh , Colette Song
IPC分类号： A61K38/00 , C07K14/47 , C07K14/725 , C07K14/74
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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17.发明授权公开(公告)号：US10899812B2
公开(公告)日：2021-01-26
申请号：US16916833
申请日：2020-06-30
发明人： Heiko Schuster , Annika Sonntag , Daniel Johannes Kowalewski , Oliver Schoor , Jens Fritsche , Toni Weinschenk , Harpreet Singh , Colette Song
IPC分类号： A61K38/00 , C07K14/47 , C07K14/725 , C07K14/74
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10435455B1
公开(公告)日：2019-10-08
申请号：US16503882
申请日：2019-07-05
发明人： Annika Sonntag , Toni Weinschenk , Andrea Mahr , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： C07K14/74 , A61K35/17 , A61K38/17 , A61P35/00 , A61P37/04 , A61K38/04 , C07K7/06 , G01N33/574 , C12N5/0783 , C12Q1/6886 , C12N15/115 , C07K16/28 , C07K14/725 , A61K39/00 , G16B25/00
摘要： A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has melanoma. A method of treating a patient who has melanoma includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the melanoma.
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公开(公告)号：US20190040112A1
公开(公告)日：2019-02-07
申请号：US16162333
申请日：2018-10-16
发明人： Annika Sonntag , Toni Weinschenk , Andrea Mahr , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： C07K14/74 , C07K16/28 , G01N33/574 , A61K39/00 , C12N5/0783 , C07K14/725 , G06F19/20 , A61K38/17 , C12Q1/6886 , A61K35/17 , C12N15/115
摘要： A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has melanoma. A method of treating a patient who has melanoma includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the melanoma.
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公开(公告)号：US10035838B2
公开(公告)日：2018-07-31
申请号：US15489399
申请日：2017-04-17
发明人： Annika Sonntag , Toni Weinschenk , Andrea Mahr , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： C07K14/74 , C07K16/28 , C07K14/725 , A61K35/17 , A61K39/00 , C12N15/115 , C12N5/0783 , G01N33/574 , G06F19/20 , C12Q1/6886
CPC分类号： C07K14/70539 , A61K35/17 , A61K38/04 , A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61P35/00 , A61P37/04 , C07K7/06 , C07K14/7051 , C07K16/2833 , C12N5/0636 , C12N5/0638 , C12N15/115 , C12N2310/16 , C12N2502/11 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/574 , G01N33/57484 , G01N2333/70539 , G16B25/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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