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公开(公告)号：US12097249B2
公开(公告)日：2024-09-24
申请号：US17581049
申请日：2022-01-21
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh , Phillip Mueller , Julia Leibold , Valentina Goldfinger
IPC分类号： A61K39/00 , C07K14/47 , C07K14/725 , C07K16/30 , C12N5/0783 , C12N15/115 , C12Q1/6886 , G01N33/574 , G01N33/68 , A61K38/00
CPC分类号： A61K39/0011 , C07K14/47 , C07K14/4748 , C07K14/7051 , C07K16/30 , C12N5/0636 , C12N15/115 , C12Q1/6886 , G01N33/5748 , G01N33/6848 , A61K38/00 , A61K2039/5158 , A61K2039/572 , C07K2319/00 , C12N2310/16 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/57407 , G01N2570/00 , G01N2800/52
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US12060399B2
公开(公告)日：2024-08-13
申请号：US17471754
申请日：2021-09-10
发明人： Heiko Schuster , Annika Sonntag , Daniel Johannes Kowalewski , Oliver Schoor , Jens Fritsche , Toni Weinschenk , Harpreet Singh , Colette Song
IPC分类号： C07K14/00 , C07K14/47 , C07K14/725 , C07K14/74 , A61K38/00
CPC分类号： C07K14/4748 , C07K14/7051 , C07K14/70539 , A61K38/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US12036271B2
公开(公告)日：2024-07-16
申请号：US17838017
申请日：2022-06-10
发明人： Andrea Mahr , Toni Weinschenk , Anita Wiebe , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K38/08 , A61K35/17 , A61K39/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/74 , C07K16/28 , C12N5/0783 , C12N15/115
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/08 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/70539 , C07K16/2833 , C12N5/0638 , C12N15/115 , A61K2039/5158 , C07K2319/00 , C12N2310/16 , C12N2501/2302 , C12N2501/2307 , C12N2501/51 , C12N2501/515
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US12023372B2
公开(公告)日：2024-07-02
申请号：US17675492
申请日：2022-02-18
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K39/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/725 , C07K14/74 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N15/115 , C12Q1/6886 , G01N33/574
CPC分类号： A61K39/0011 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K14/7051 , C07K14/70539 , C07K16/2833 , C07K16/3076 , C12N5/0636 , C12N15/115 , C12Q1/6886 , G01N33/57492 , A61K39/00 , A61K2039/5158 , C07K2319/40 , C12N2310/16 , C12N2501/50 , C12Q2600/106 , C12Q2600/156 , G01N2333/70539
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US12018064B2
公开(公告)日：2024-06-25
申请号：US17396305
申请日：2021-08-06
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh , Lea Stevermann
IPC分类号： A61K38/00 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/17 , A61K39/00 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/725 , C07K14/74 , C07K16/18 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N9/64 , C12Q1/6886 , G01N33/50 , G01N33/566 , G01N33/569
CPC分类号： C07K14/70539 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/1774 , A61K39/0005 , A61K39/0011 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K14/4748 , C07K14/7051 , C07K16/18 , C07K16/2833 , C07K16/30 , C12N5/0636 , C12N5/0638 , C12N9/6491 , C12Q1/6886 , G01N33/505 , G01N33/5088 , G01N33/566 , G01N33/56972 , G01N33/56977 , A61K38/00 , A61K2039/5158 , A61K2039/54 , A61K2039/57 , A61K2039/572 , A61K2039/585 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N2501/998 , C12N2502/11 , C12Q2600/106 , C12Q2600/158 , C12Y304/24 , G01N2333/47 , G01N2333/70503 , G01N2333/7051 , G01N2333/70539 , G01N2500/10
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US12006349B2
公开(公告)日：2024-06-11
申请号：US17396323
申请日：2021-08-06
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh , Lea Stevermann
IPC分类号： A61K38/00 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/17 , A61K39/00 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/725 , C07K14/74 , C07K16/18 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N9/64 , C12Q1/6886 , G01N33/50 , G01N33/566 , G01N33/569
CPC分类号： C07K14/70539 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/1774 , A61K39/0005 , A61K39/0011 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K14/4748 , C07K14/7051 , C07K16/18 , C07K16/2833 , C07K16/30 , C12N5/0636 , C12N5/0638 , C12N9/6491 , C12Q1/6886 , G01N33/505 , G01N33/5088 , G01N33/566 , G01N33/56972 , G01N33/56977 , A61K38/00 , A61K2039/5158 , A61K2039/54 , A61K2039/57 , A61K2039/572 , A61K2039/585 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N2501/998 , C12N2502/11 , C12Q2600/106 , C12Q2600/158 , C12Y304/24 , G01N2333/47 , G01N2333/70503 , G01N2333/7051 , G01N2333/70539 , G01N2500/10
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US11957742B2
公开(公告)日：2024-04-16
申请号：US18158604
申请日：2023-01-24
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K39/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/725 , C07K14/74 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N15/115 , C12Q1/6886 , G01N33/574
CPC分类号： A61K39/0011 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K14/7051 , C07K14/70539 , C07K16/2833 , C07K16/3076 , C12N5/0636 , C12N15/115 , C12Q1/6886 , G01N33/57492 , A61K39/00 , A61K2039/5158 , C07K2319/40 , C12N2310/16 , C12N2501/50 , C12Q2600/106 , C12Q2600/156 , G01N2333/70539
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US11952409B2
公开(公告)日：2024-04-09
申请号：US18305928
申请日：2023-04-24
发明人： Jens Hukelmann , Heiko Schuster , Lena Wullkopf , Christoph Schraeder , Jens Fritsche , Daniel Johannes Kowalewski , Michael Roemer , Oliver Schoor
IPC分类号： C07K14/725 , A61K35/17 , A61K38/00 , C07K14/74 , C07K16/28
CPC分类号： C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00 , C07K2319/30
摘要： The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11951160B2
公开(公告)日：2024-04-09
申请号：US17669454
申请日：2022-02-11
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K39/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/725 , C07K14/74 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N15/115 , C12Q1/6886 , G01N33/574
CPC分类号： A61K39/0011 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K14/7051 , C07K14/70539 , C07K16/2833 , C07K16/3076 , C12N5/0636 , C12N15/115 , C12Q1/6886 , G01N33/57492 , A61K39/00 , A61K2039/5158 , C07K2319/40 , C12N2310/16 , C12N2501/50 , C12Q2600/106 , C12Q2600/156 , G01N2333/70539
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US11951132B2
公开(公告)日：2024-04-09
申请号：US17377735
申请日：2021-07-16
发明人： Heiko Schuster , Franziska Hoffgaard , Jens Fritsche , Oliver Schoor , Toni Weinschenk , Daniel Johannes Kowalewski , Chih-Chiang Tsou
IPC分类号： A61K39/00 , A61K35/17 , A61K38/08 , A61K39/12 , A61K39/39 , A61K39/395 , A61K45/06 , A61P35/00 , A61P35/02 , C07K7/06 , C07K14/47 , C07K14/54 , C07K16/24 , C07K16/28 , C12N5/0783 , A61K45/00
CPC分类号： A61K35/17 , A61K38/08 , A61K39/001102 , A61K39/001114 , A61K39/001118 , A61K39/12 , A61K39/39 , A61K39/39558 , A61K45/06 , A61P35/00 , A61P35/02 , C07K7/06 , C07K14/4748 , C07K14/5434 , C07K16/244 , C07K16/2818 , C07K16/2821 , C12N5/0636 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/55533 , A61K2039/55538 , A61K2039/55561 , A61K2039/572 , A61K2039/585 , A61K45/05
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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