公开(公告)号：US10344087B2

公开(公告)日：2019-07-09

申请号：US14767600

申请日：2014-02-13

Applicant: INNATE PHARMA

Inventor： Cécile Bonnafous ,  Hélène Sicard ,  Renaud Buffet ,  Mathieu Blery

IPC: A61K39/00 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: The present disclosure relates to methods for the treatment, prevention and diagnosis of peripheral T-cell lymphoma using compounds that specifically bind NKp46. Included in particular are compounds that bind NKp46 and deplete tumor cells that express NKp46 at their surface, and pharmaceutical compositions comprising the same. The disclosure also relates to the use of antibodies that specifically bind NKp46 in diagnostic and theranostic assays in the detection and treatment of peripheral T-cell lymphoma.

公开(公告)号：US20150191542A1

公开(公告)日：2015-07-09

申请号：US14377274

申请日：2013-02-07

Applicant: INNATE PHARMA, S.A.

Inventor： Mathieu Blery ,  Laurent Gauthier ,  Ivan Perrot ,  Cecile Bonnafous

IPC: C07K16/28 ,  G01N33/569

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2833 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56977 ,  G01N2333/70539

Abstract: The present invention relates to methods for the treatment of disorders mediated by MICA-expressing cells using antibodies, antibody fragments, and derivatives thereof that specifically bind MICA. The invention also relates to antibodies; cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; and pharmaceutical compositions comprising the same.

Abstract translation: 本发明涉及使用特异性结合MICA的抗体，抗体片段及其衍生物治疗由MICA表达细胞介导的病症的方法。 本发明还涉及抗体; 产生这种抗体的细胞; 制备此类抗体的方法; 抗体的片段，变体和衍生物; 和包含其的药物组合物。