公开(公告)号：US20200004925A1

公开(公告)日：2020-01-02

申请号：US16022088

申请日：2018-06-28

申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION

发明人： Filippo Utro ,  Kahn Rhrissorrakrai ,  Chaya Levovitz ,  Laxmi Parida

IPC分类号： G06F19/14 ,  G06F19/24 ,  G16H50/20

摘要： A computer-implemented method includes determining, by a processor, from a time-series evolution tree comprising one or more clones at each of the plurality of time points, that the one or more clones are sensitive clones or resistant clones, wherein the time-series evolution tree is based on sequence data for a tumor from a subject at a plurality of time points, wherein each time point in the time-series evolution tree represents an event in the subject's cancer treatment, and wherein a clone is a collection of gene alterations; based at least in part on determining that the one or more clones that are the sensitive or resistant clones, determining, by the processor, a geneset composition of the one or more clones that are the sensitive or resistant clones; and based at least in part on determining the geneset composition, determining by the processor, a further treatment for the subject.