公开(公告)号：US20250019377A1

公开(公告)日：2025-01-16

申请号：US18684205

申请日：2022-08-17

Applicant: JACOBIO PHARMACEUTICALS CO., LTD

Inventor： Hongwei YANG ,  Cunbo MA ,  Panliang GAO ,  Huifeng HAN ,  Peng WANG ,  Runze LI ,  Xiaoyu LIU ,  Yanping WANG ,  Wei LONG ,  Wei ZHANG

IPC: C07D471/04 ,  A61K31/553 ,  A61P35/00 ,  C07D413/14 ,  C07D487/04 ,  C07D519/00

Abstract: A Compound of formula (I) or (II), a stereoisomer thereof, an atropisomer, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer, a pharmaceutically acceptable salt of the atropisomer, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof is disclosed:

公开(公告)号：US20210292331A1

公开(公告)日：2021-09-23

申请号：US17197095

申请日：2021-03-10

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Amin LI ,  Sujing LI ,  Peng WANG ,  Chaojie DANG ,  Dan LIU

IPC: C07D487/04 ,  A61K9/00 ,  A61P35/00

Abstract: The invention relates to a KRAS mutant protein inhibitor shown as formula (I), a composition containing the inhibitor and the use thereof.