公开(公告)号：US20220213109A1

公开(公告)日：2022-07-07

申请号：US17562492

申请日：2021-12-27

Applicant: JACOBIO PHARMACEUTICALS CO., LTD

Inventor： Amin LI ,  Sujing LI ,  Peng WANG ,  Chaojie DANG ,  Dan LIU

IPC: C07D487/04 ,  A61P35/00 ,  A61K9/00

Abstract: The invention relates to a KRAS mutant protein inhibitor shown as formula (I), a composition containing the inhibitor and the use thereof.

公开(公告)号：US20210094919A1

公开(公告)日：2021-04-01

申请号：US17030626

申请日：2020-09-24

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Amin LI ,  Sujing LI ,  Peng WANG ,  Chaojie DANG ,  Dan LIU

IPC: C07D221/04

Abstract: The invention relates to a KRAS mutant protein inhibitor, a composition containing the inhibitor and the use thereof.

公开(公告)号：US20240400591A1

公开(公告)日：2024-12-05

申请号：US18682463

申请日：2022-08-09

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Sujing LI ,  Amin LI ,  Qian ZHENG ,  Chaojie DANG ,  Xinrui FAN ,  Wei LONG ,  Yanping WANG

IPC: C07F9/6558 ,  A61K31/397 ,  A61K31/403 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/67 ,  A61K31/675 ,  C07D333/58 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/04 ,  C07D491/107 ,  C07D495/04 ,  C07F9/6568 ,  C07F9/6584

Abstract: Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.

公开(公告)号：US20210292331A1

公开(公告)日：2021-09-23

申请号：US17197095

申请日：2021-03-10

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Amin LI ,  Sujing LI ,  Peng WANG ,  Chaojie DANG ,  Dan LIU

IPC: C07D487/04 ,  A61K9/00 ,  A61P35/00

Abstract: The invention relates to a KRAS mutant protein inhibitor shown as formula (I), a composition containing the inhibitor and the use thereof.

公开(公告)号：US20230011726A1

公开(公告)日：2023-01-12

申请号：US17407418

申请日：2021-08-20

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Amin LI ,  Sujing LI ,  Peng WANG ,  Chaojie DANG ,  Dan LIU

IPC: C07D487/04 ,  A61P35/00 ,  A61K9/00

Abstract: The invention relates to a KRAS mutant protein inhibitor shown as formula (I), a composition containing the inhibitor and the use thereof.

公开(公告)号：US20210300920A1

公开(公告)日：2021-09-30

申请号：US17218568

申请日：2021-03-31

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Amin LI ,  Sujing LI ,  Peng WANG ,  Chaojie DANG ,  Dan LIU

IPC: C07D471/04

Abstract: The invention relates to a KRAS mutant protein inhibitors of formula (I), a composition containing the inhibitors and the use thereof.