公开(公告)号：US08282970B2

公开(公告)日：2012-10-09

申请号：US12574862

申请日：2009-10-07

申请人： Xiaowei Shi ,  Xueyin Ren ,  Jianhong Liu ,  Houjian Cao ,  Wenhao Ren ,  Yizhou Cao

发明人： Xiaowei Shi ,  Xueyin Ren ,  Jianhong Liu ,  Houjian Cao ,  Wenhao Ren ,  Yizhou Cao

IPC分类号： A61K36/82

CPC分类号： A61K36/82 ,  A61K31/351

摘要： A process for producing purified theaflavin extract is provided which comprises combining an organic solvent with tea leaves, extracting polyphenols from the tea leaves to produce an organic stock substrate solution; producing a second batch of tea leaves; grinding the second batch of tea leaves to produce stock fermentation enzyme; combining the stock substrate solution with the stock fermentation enzyme to produce a fermentation mixture; fermentation of the mixture to produce theaflavins; and, separating the theaflavins from the fermentation mixture to produce purified theaflavin extract. Oral dosage forms are provided which comprise an effective amount of the purified theaflavin extract. Methods of treatment of human physiological disorders are provided which comprise administering an oral dosage form.

摘要翻译： 提供一种生产纯化的茶黄素提取物的方法，其包括将有机溶剂与茶叶组合，从茶叶中提取多酚以产生有机原料溶液; 生产第二批茶叶; 研磨第二批茶叶生产发酵酶; 将原料基质溶液与原料发酵酶组合以产生发酵混合物; 发酵混合物生产茶黄素; 并将茶黄素与发酵混合物分离以产生纯化的茶黄素提取物。 提供包含有效量的纯化的茶黄素提取物的口服剂型。 提供了治疗人类生理紊乱的方法，其包括施用口服剂型。