公开(公告)号：US20220409550A1

公开(公告)日：2022-12-29

申请号：US17843418

申请日：2022-06-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： In-San KIM ,  Eun Jung LEE ,  Gi-hoon NAM ,  Gi-beom KIM ,  Hyo-Dong SUNG

IPC: A61K9/51 ,  C07K14/79 ,  A61P35/00

Abstract: Provided are a programmed cell death protein 1 (PD-1)-decorated nanocage and use thereof. The PD-1-decorated nanocage (PdNC) of the present disclosure may block PD-1 and programmed cell death-ligand (PD-L) signaling and may induce anti-tumor immunity activation at two immune checkpoints of tumor microenvironment (TME) (effector phase) and tumor-draining lymph node (TDLN) (innate phase), thereby increasing the adaptability of PD-1 and PD-L blockade-based therapy. Accordingly, it may be applied to various kinds of cancer therapies.