公开(公告)号：US06599705B2

公开(公告)日：2003-07-29

申请号：US09863040

申请日：2001-05-22

申请人： Steffen Rupp ,  Laura Robertson ,  Eric F. Summers ,  Peter Hecht ,  Radclyffe Roberts ,  Hiten Madhani ,  Cora Ann Styles ,  Hsiu-Jung Lo ,  Amir Sherman ,  Brian Cali ,  Gerald R. Fink

发明人： Steffen Rupp ,  Laura Robertson ,  Eric F. Summers ,  Peter Hecht ,  Radclyffe Roberts ,  Hiten Madhani ,  Cora Ann Styles ,  Hsiu-Jung Lo ,  Amir Sherman ,  Brian Cali ,  Gerald R. Fink

IPC分类号： C12Q168

CPC分类号： C12Q1/18 ,  G01N2500/10

摘要： Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.

公开(公告)号：US20070196378A1

公开(公告)日：2007-08-23

申请号：US10593213

申请日：2005-03-15

申请人： Henrike Lotz ,  Herwig Brunner ,  Steffen Rupp

发明人： Henrike Lotz ,  Herwig Brunner ,  Steffen Rupp

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/569 ,  C07H21/04 ,  A61K39/395 ,  C12N9/48 ,  C12N1/18 ,  C12N1/16 ,  C12N15/74

CPC分类号： C07K14/40

摘要： Nucleic acids that code a cell wall protein required for the hyphal development of Candida; fragments of the nucleic acids; vectors containing the nucleic acids or nucleic acid fragments; host cells containing the vectors; cell wall proteins coded by the nucleic acids; antibodies directed against the proteins; methods for producing the cell wall proteins; methods for characterizing and/or for detecting the hyphal stage of Candida; methods for detecting a Candida infection; methods for identifying substances having a therapeutic effect against diseases caused by Candida; diagnostic and pharmaceutical compositions containing the nucleic acid, nucleic acids fragments, vectors, host cells, proteins and/or antibodies directed against the cell wall protein; kits for conducting in-vitro indentation of the cell wall proteins, and; to the use of the nucleic acids, vectors, proteins or antibodies for diagnosing and treating Candida-caused diseases, i.e., producing diagnostic or pharmaceutical compositions.

摘要翻译： 编码念珠菌菌丝体发育所需的细胞壁蛋白的核酸; 核酸片段; 含有核酸或核酸片段的载体; 含有载体的宿主细胞; 由核酸编码的细胞壁蛋白; 针对蛋白质的抗体; 生产细胞壁蛋白的方法; 表征和/或检测假丝酵母菌丝阶段的方法; 检测念珠菌感染的方法; 用于鉴定具有针对由念珠菌引起的疾病的治疗效果的物质的方法; 含有针对细胞壁蛋白的核酸，核酸片段，载体，宿主细胞，蛋白质和/或抗体的诊断和药物组合物; 用于进行细胞壁蛋白的体外压痕的试剂盒，和 涉及使用核酸，载体，蛋白质或抗体来诊断和治疗念珠菌引起的疾病，即产生诊断或药物组合物。