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11.发明授权公开(公告)号：US09402542B2
公开(公告)日：2016-08-02
申请号：US13540626
申请日：2012-07-03
Applicant: Lawrence W. Stark , Claudio Privitera , Kamran Siminou , Jeffrey Oliver
Inventor： Lawrence W. Stark , Claudio Privitera , Kamran Siminou , Jeffrey Oliver
CPC classification number: A61B3/112 , A61B5/16 , A61N1/36046 , A61N2005/0648
Abstract: A system for use during a medical procedure. The system includes a pupilometer for obtaining data descriptive of one or more pupilary characteristics from an eye of a subject, and means for delivering a noxious stimulus. The means for delivering a noxious stimulus is in communication with the pupilometer and is activated by the pupilometer thereby sending a noxious stimulus to an anatomical structure of the patient.
Abstract translation: 在医疗过程中使用的系统。 该系统包括用于从对象的眼睛获得描述一个或多个瞳孔特征的数据的瞳孔仪，以及用于递送有害刺激的装置。 用于传递有害刺激的手段与瞳孔仪通信，并由瞳孔仪激活，从而向患者的解剖结构发送有害的刺激。
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公开(公告)号：US09220408B2
公开(公告)日：2015-12-29
申请号：US14571276
申请日：2014-12-15
Applicant: Claudio Privitera , Kamran Siminou
Inventor： Claudio Privitera , Kamran Siminou
CPC classification number: A61B3/112 , A61B3/0025 , A61B3/0083 , A61B3/113 , A61B3/14 , A61B3/145 , A61B5/4011 , A61B5/7203 , A61B2560/0425
Abstract: A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source, such as a pupilometer and determining whether one of various pupillary response conditions is met.
Abstract translation: 公开了一种筛选受试者的瞳孔以确定瞳孔反射是否类似于典型瞳孔反射的方法。 该方法包括以刺激源（例如瞳孔仪）刺激瞳孔并确定是否满足各种瞳孔反应条件之一的步骤。
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公开(公告)号：US08393734B2
公开(公告)日：2013-03-12
申请号：US12210185
申请日：2008-09-13
Applicant: Claudio Privitera , Kamran Siminou
Inventor： Claudio Privitera , Kamran Siminou
CPC classification number: A61B3/112 , A61B3/0025 , A61B3/0083 , A61B3/113 , A61B3/14 , A61B3/145 , A61B5/4011 , A61B5/7203 , A61B2560/0425
Abstract: A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source. The method further includes the steps of using a pupilometer to track the pupil's constriction response over a duration of time, wherein the step of tracking the pupil constriction response begins substantially simultaneously with or immediately subsequent to time 0 and lasts for a period of time y, and using the pupilometer to collect a plurality of data points in which each data point corresponds with a diameter of the pupil at a specific time within the time duration y. The method further includes the step of generating a pupil data profile by compiling the data points and determining whether one or more conditions arc met. wherein the one or more conditions comprises the following: (a) more than two data points exist representing the same pupil diameter at three or more separate times during duration y; (b) a first phase of the pupilary reflex response exists, wherein said first phase is characterized by a period of non-constriction immediately subsequent to time 0, said first phase having a duration of less than about 100 msec or greater than about 1000 msec; (c) if two data points exist representing the same pupil diameter at two separate times y1 and y2 during duration y, then the duration of time between y1 and y2 is less than about 100 msec; or during the first phase of the pupilary reflex, the diameter of the pupil increases before it decreases. Existence of one of said conditions indicates that the pupil reflex does not resemble a canonical reflex.
Abstract translation: 公开了一种筛选受试者的瞳孔以确定瞳孔反射是否类似于典型瞳孔反射的方法。 该方法包括用刺激源刺激瞳孔的步骤。 该方法还包括以下步骤：使用瞳孔仪在一段时间内跟踪瞳孔的收缩反应，其中跟踪瞳孔收缩反应的步骤基本上与时间0同时或紧随时刻0开始并持续一段时间y， 并且使用瞳孔仪来收集在该持续时间y内的特定时刻每个数据点与瞳孔的直径对应的多个数据点。 该方法还包括通过编译数据点并确定是否满足一个或多个条件来生成瞳孔数据简档的步骤。 其中所述一个或多个条件包括以下内容：（a）在持续时间y期间在三个或更多个分开的时间存在多于两个表示相同瞳孔直径的数据点; （b）存在瞳孔反射响应的第一阶段，其中所述第一阶段的特征在于在时间0之后的非收缩期，所述第一阶段具有小于约100毫秒或大于约1000毫秒的持续时间 ; （c）如果在持续时间y期间在两个分开的时间y1和y2处存在两个数据点，表示相同的瞳孔直径，则y1和y2之间的持续时间小于约100毫秒; 或在瞳孔反射的第一阶段期间，瞳孔的直径在减小之前增加。 存在所述条件之一表明瞳孔反射不像典型的反射。
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14.发明授权Pupilometer with pupil irregularity detection, pupil tracking, and pupil response detection capability, glaucoma screening capability, intracranial pressure detection capability, and ocular aberration measurement capability 有权具有瞳孔不规则检测，瞳孔跟踪和瞳孔反应检测能力的青光眼测光仪，青光眼筛查能力，颅内压检测能力和眼睛像差测量能力公开(公告)号：US08235526B2
公开(公告)日：2012-08-07
申请号：US12704527
申请日：2010-02-12
Applicant: Lawrence W. Stark , Claudio Privitera , Kamran Siminou , Jeffrey Oliver
Inventor： Lawrence W. Stark , Claudio Privitera , Kamran Siminou , Jeffrey Oliver
IPC: A61B3/10
CPC classification number: A61B3/112 , A61B5/16 , A61N1/36046 , A61N2005/0648
Abstract: A pupilometer that has image capturing means, a light source that emits light; and imaging software that processes image data obtained by the image capturing means and produces an output is described. The output comprises a single scalar value indicative of a neurological condition of a patient, wherein the scalar value can be applied to a scale indicative of a neurological condition. The image data comprises one or more components of the pupil's dynamic response to light emitted by the light source.
Abstract translation: 具有图像拍摄装置，发光的光源的瞳孔仪; 以及处理由图像捕获装置获得的图像数据并产生输出的成像软件。 该输出包括指示患者的神经状态的单个标量值，其中标量值可以应用于指示神经病症的比例。 图像数据包括瞳孔对光源发出的光的动态响应的一个或多个分量。
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15.发明申请METHODS, SYSTEMS, AND DEVICES FOR MONITORING ANISOCORIA AND ASYMMETRY OF PUPILLARY REACTION TO STIMULUS 有权用于监测异位症的方法，系统和装置以及对刺激反应的不对称性公开(公告)号：US20110228224A1
公开(公告)日：2011-09-22
申请号：US13149926
申请日：2011-06-01
Applicant: Kamran Siminou
Inventor： Kamran Siminou
CPC classification number: A61B3/112 , A61B3/0025 , A61B3/0058 , A61B3/14
Abstract: A Pupillometer is disclosed. The Pupillometer has a display, an imaging apparatus that has a pupil finder and a microprocessor, and a memory in communication with the microprocessor. The display is sized to simultaneously display a video of y or more seconds in length of a left pupil and a video of y or more seconds in length of a right pupil. The pupil finder identifies the perimeter of a pupil. The imaging apparatus is capable of recording images of an individual's pupils at a rate of x image frames per second for a period of y or more seconds and playing back said image frames as a video at x image frames per second or at another rate that is faster or slower than x image frames per second. The memory has stored therein a program for enabling said microprocessor to do the following: (i) identify a center of the left pupil and a center of the right pupil for each image frame; (ii) synchronize each image frame of the two videos starting from the first frame; (iii) cause the display to display the two videos simultaneously such that each of the image frames of the video of the left eye is synchronized to a corresponding image frame of the video of the right eye when played back on the display; and (iv) cause the two videos to be displayed so that the center of the left pupil in each image frame is aligned on the display with the center of the right pupil for the corresponding image frame.
Abstract translation: 披露了一种瞳孔计 瞳孔计具有显示器，具有瞳孔取景器和微处理器的成像装置以及与微处理器通信的存储器。 显示器的大小可同时显示左瞳孔长度为y或更多秒的视频以及右瞳孔长度为y或更长秒的视频。 瞳孔探测器识别瞳孔的周长。 成像装置能够以y或更多秒的时间以每秒x个图像帧的速率记录个人瞳孔的图像，并且以每秒x个图像帧的速度播放作为视频的所述图像帧，或以另外的速率 比每秒x个图像帧更快或更慢。 存储器中存储有用于使所述微处理器执行以下操作的程序：（i）为每个图像帧识别左瞳孔的中心和右瞳孔的中心; （ii）从第一帧开始同步两个视频的每个图像帧; （iii）使显示器同时显示两个视频，使得在显示器上播放时，左眼视频的每个图像帧与右眼视频的相应图像帧同步; 和（iv）使两个视频被显示，使得每个图像帧中的左瞳孔的中心与显示器对准用于相应图像帧的右瞳孔的中心。
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Patent Agency Ranking
16.发明授权Methods, systems, and devices for monitoring anisocoria and asymmetry of pupillary reaction to stimulus 有权用于监测不良反应的方法，系统和装置以及对刺激的瞳孔反应的不对称性公开(公告)号：US07967442B2
公开(公告)日：2011-06-28
申请号：US12626452
申请日：2009-11-25
Applicant: Kamran Siminou
Inventor： Kamran Siminou
IPC: A61B9/00
CPC classification number: A61B3/112 , A61B3/0025 , A61B3/0058 , A61B3/14
Abstract: A Pupillometer is disclosed. The Pupillometer has a display, an imaging apparatus that has a pupil finder and a microprocessor, and a memory in communication with the microprocessor. The display is sized to simultaneously display a video of y or more seconds in length of a left pupil and a video of y or more seconds in length of a right pupil. The pupil finder identifies the perimeter of a pupil. The imaging apparatus is capable of recording images of an individual's pupils at a rate of x image frames per second for a period of y or more seconds and playing back said image frames as a video at x image frames per second or at another rate that is faster or slower than x image frames per second. The memory has stored therein a program for enabling said microprocessor to do the following: (i) identify a center of the left pupil and a center of the right pupil for each image frame; (ii) synchronize each image frame of the two videos starting from the first frame; (iii) cause the display to display the two videos simultaneously such that each of the image frames of the video of the left eye is synchronized to a corresponding image frame of the video of the right eye when played back on the display; and (iv) cause the two videos to be displayed so that the center of the left pupil in each image frame is aligned on the display with the center of the right pupil for the corresponding image frame.
Abstract translation: 披露了一种瞳孔计 瞳孔计具有显示器，具有瞳孔取景器和微处理器的成像装置以及与微处理器通信的存储器。 显示器的大小可同时显示左瞳孔长度为y或更多秒的视频以及右瞳孔长度为y或更长秒的视频。 瞳孔探测器识别瞳孔的周长。 成像装置能够以y或更多秒的时间以每秒x个图像帧的速率记录个人瞳孔的图像，并且以每秒x个图像帧的速度播放作为视频的所述图像帧，或以另外的速率 比每秒x个图像帧更快或更慢。 存储器中存储有用于使所述微处理器执行以下操作的程序：（i）为每个图像帧识别左瞳孔的中心和右瞳孔的中心; （ii）从第一帧开始同步两个视频的每个图像帧; （iii）使显示器同时显示两个视频，使得在显示器上播放时，左眼视频的每个图像帧与右眼视频的相应图像帧同步; 和（iv）使两个视频被显示，使得每个图像帧中的左瞳孔的中心与显示器对准用于相应图像帧的右瞳孔的中心。
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公开(公告)号：US07901079B2
公开(公告)日：2011-03-08
申请号：US12822170
申请日：2010-06-23
Applicant: Kamran Siminou , Jeffrey Oliver
Inventor： Kamran Siminou , Jeffrey Oliver
CPC classification number: A61B3/0083 , A61B3/10 , A61B3/185
Abstract: An ophthalmic examination system comprising a headrest with a detection element, and an ophthalmic instrument (OI) having a microprocessor and a sensor in communication with the microprocessor. The sensor is configured to detect the presence of the detection element, and the headrest is configured for coupling to the OI.
Abstract translation: 一种眼科检查系统，包括具有检测元件的头枕和具有微处理器和与微处理器通信的传感器的眼科仪器（OI）。 传感器被配置为检测检测元件的存在，头枕被配置为耦合到OI。
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公开(公告)号：US20100259725A1
公开(公告)日：2010-10-14
申请号：US12822170
申请日：2010-06-23
Applicant: Kamran Siminou , Jeffrey Oliver
Inventor： Kamran Siminou , Jeffrey Oliver
IPC: A61B3/10
CPC classification number: A61B3/0083 , A61B3/10 , A61B3/185
Abstract: An ophthalmic examination system comprising a headrest with a detection element, and an ophthalmic instrument (OI) having a microprocessor and a sensor in communication with the microprocessor. The sensor is configured to detect the presence of the detection element, and the headrest is configured for coupling to the OI.
Abstract translation: 一种眼科检查系统，包括具有检测元件的头枕和具有微处理器和与微处理器通信的传感器的眼科仪器（OI）。 传感器被配置为检测检测元件的存在，头枕被配置为耦合到OI。
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公开(公告)号：US20090141239A1
公开(公告)日：2009-06-04
申请号：US12367513
申请日：2009-02-07
Applicant: Kamran Siminou , Jeffrey Oliver
Inventor： Kamran Siminou , Jeffrey Oliver
IPC: A61B3/00
CPC classification number: A61B3/0083 , A61B3/10 , A61B3/185
Abstract: An ophthalmic examination system comprising a headrest with a detection element, and an ophthalmic instrument (OI) having a microprocessor and a sensor in communication with the microprocessor. The sensor is configured to detect the presence of the detection element, and the headrest is configured for coupling to the OI.
Abstract translation: 一种眼科检查系统，包括具有检测元件的头枕和具有微处理器和与微处理器通信的传感器的眼科仪器（OI）。 传感器被配置为检测检测元件的存在，头枕被配置为耦合到OI。
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公开(公告)号：US07488074B2
公开(公告)日：2009-02-10
申请号：US11800333
申请日：2007-05-05
Applicant: Kamran Siminou , Jeffrey Oliver
Inventor： Kamran Siminou , Jeffrey Oliver
CPC classification number: A61B3/0083 , A61B3/10 , A61B3/185
Abstract: An ophthalmic examination system comprising a headrest with a detection element, and an ophthalmic instrument (OI) having a microprocessor and a sensor in communication with the microprocessor. The sensor is configured to detect the presence of the detection element, and the headrest is configured for coupling to the OI.
Abstract translation: 一种眼科检查系统，包括具有检测元件的头枕和具有微处理器和与微处理器通信的传感器的眼科仪器（OI）。 传感器被配置为检测检测元件的存在，头枕被配置为耦合到OI。
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