公开(公告)号：US08534840B2

公开(公告)日：2013-09-17

申请号：US13149926

申请日：2011-06-01

Applicant: Kamran Siminou

Inventor： Kamran Siminou

IPC: A61B3/00

CPC classification number: A61B3/112 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/14

Abstract: A Pupillometer is disclosed. The Pupillometer has a display, an imaging apparatus that has a pupil finder and a microprocessor, and a memory in communication with the microprocessor. The display is sized to simultaneously display a video of y or more seconds in length of a left pupil and a video of y or more seconds in length of a right pupil. The pupil finder identifies the perimeter of a pupil. The imaging apparatus is capable of recording images of an individual's pupils at a rate of x image frames per second for a period of y or more seconds and playing back said image frames as a video at x image frames per second or at another rate that is faster or slower than x image frames per second. The memory has stored therein a program for enabling said microprocessor to do the following: (i) identify a center of the left pupil and a center of the right pupil for each image frame; (ii) synchronize each image frame of the two videos starting from the first frame; (iii) cause the display to display the two videos simultaneously such that each of the image frames of the video of the left eye is synchronized to a corresponding image frame of the video of the right eye when played back on the display; and (iv) cause the two videos to be displayed so that the center of the left pupil in each image frame is aligned on the display with the center of the right pupil for the corresponding image frame.

Abstract translation: 披露了一种瞳孔计 瞳孔计具有显示器，具有瞳孔取景器和微处理器的成像装置以及与微处理器通信的存储器。 显示器的大小可同时显示左瞳孔长度为y或更多秒的视频以及右瞳孔长度为y或更长秒的视频。 瞳孔探测器识别瞳孔的周长。 成像装置能够以y或更多秒的时间以每秒x个图像帧的速率记录个人瞳孔的图像，并且以每秒x个图像帧的速度播放作为视频的所述图像帧，或以另外的速率 比每秒x个图像帧更快或更慢。 存储器中存储有用于使所述微处理器执行以下操作的程序：（i）为每个图像帧识别左瞳孔的中心和右瞳孔的中心; （ii）从第一帧开始同步两个视频的每个图像帧; （iii）使显示器同时显示两个视频，使得在显示器上播放时，左眼视频的每个图像帧与右眼视频的相应图像帧同步; 和（iv）使两个视频被显示，使得每个图像帧中的左瞳孔的中心与显示器对准用于相应图像帧的右瞳孔的中心。

公开(公告)号：US20090306538A1

公开(公告)日：2009-12-10

申请号：US12436469

申请日：2009-05-06

Applicant: Kamran Siminou

Inventor： Kamran Siminou

IPC: A61B3/11

CPC classification number: A61B3/112 ,  A61B5/031 ,  A61B5/4076

Abstract: Methods, systems and devices for determining whether a patient has an abnormally high level of intracranial pressure is described. The method includes using a pupillometer to obtain pupillary response data from the patient. The pupillary response data can be representative of one or more pupillary response characteristics of the patient. The method further includes providing a data analysis system comprising a microprocessor that is in communication with the pupillometer. The microprocessor includes an algorithm that converts the pupillary response data to a scalar value that is indicative of the patient's level of intracranial pressure. The microprocessor can be a stand-alone computer connected to the pupillometer or it can be integral with the pupillometer. The method further includes using the data analysis system to derive a scalar value based on the pupillary response data from the patient, wherein the scalar value is indicative of the patient's level of intracranial pressure. The scalar value can be represented by a numerical value, graphical depiction, color, sound, or other visual or audio means that indicates a value. The scalar value can be a Scalar value that indicates that the patient's pupillary response characteristics indicate that the patient's intracranial pressure is within a normal range, an abnormal range, or that the pupillary response characteristics indicate that the pupil is non-responsive.

Abstract translation: 描述了用于确定患者是否具有异常高水平的颅内压的方法，系统和装置。 该方法包括使用瞳孔测量仪来获得患者的瞳孔反应数据。 瞳孔反应数据可以代表患者的一个或多个瞳孔反应特征。 该方法还包括提供包括与瞳孔瞳孔通信的微处理器的数据分析系统。 微处理器包括将瞳孔响应数据转换成指示患者颅内压水平的标量值的算法。 微处理器可以是连接到瞳孔尺度的独立计算机，也可以与瞳孔计一体。 该方法还包括使用数据分析系统基于来自患者的瞳孔响应数据导出标量值，其中标量值表示患者的颅内压水平。 标量值可以由数值，图形描述，颜色，声音或其他指示值的视觉或音频方式表示。 标量值可以是Scalar值，其表示患者的瞳孔反应特征表明患者的颅内压在正常范围内，异常范围内，或者瞳孔反应特征表明瞳孔不响应。

公开(公告)号：US09626578B2

公开(公告)日：2017-04-18

申请号：US13309412

申请日：2011-12-01

Applicant: Kamran Siminou

Inventor： Kamran Siminou

IPC: H04N7/18 ,  G06K9/20 ,  H04N1/195 ,  G09B21/00 ,  H04N1/00

CPC classification number: G06K9/2081 ,  G06K9/2054 ,  G06K2209/01 ,  G09B21/008 ,  H04N1/00347 ,  H04N1/19594 ,  H04N2201/0081 ,  H04N2201/0089 ,  H04N2201/043 ,  H04N2201/0436

Abstract: A viewing aid includes a camera, a viewing surface within a field of view of the camera, a memory, a display, and software programmed to track a tracking element within the field of view. Viewing material is placed on the viewing surface. The camera, viewing surface, and material all remain substantially stationary. The camera captures and stores an initial image of the material in the memory. The software then tracks the location of a tracking element within the field of view then maps the location to a portion of the initial image in memory using an X-Y coordinate system, and/or identifies character elements of the material adjacent the tracking element then maps the character elements to corresponding character elements of the initial image in memory. An enhanced image is then displayed on the display corresponding to the mapped portion of the initial image.

公开(公告)号：US20120274906A1

公开(公告)日：2012-11-01

申请号：US13543341

申请日：2012-07-06

Applicant: Claudio Privitera ,  Kamran Siminou

Inventor： Claudio Privitera ,  Kamran Siminou

IPC: A61B3/11

CPC classification number: A61B3/112 ,  A61B3/0025 ,  A61B3/0083 ,  A61B3/113 ,  A61B3/14 ,  A61B3/145 ,  A61B5/4011 ,  A61B5/7203 ,  A61B2560/0425

Abstract: A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source, such as a pupilometer and determining whether one of various pupillary response conditions is met.

Abstract translation: 公开了一种筛选受试者的瞳孔以确定瞳孔反射是否类似于典型瞳孔反射的方法。 该方法包括以刺激源（例如瞳孔仪）刺激瞳孔并确定是否满足各种瞳孔反应条件之一的步骤。

公开(公告)号：US20120268715A1

公开(公告)日：2012-10-25

申请号：US13540626

申请日：2012-07-03

Applicant: Lawrence W. Stark ,  Claudio M. Privitera ,  Kamran Siminou ,  Jeffrey Oliver

Inventor： Lawrence W. Stark ,  Claudio M. Privitera ,  Kamran Siminou ,  Jeffrey Oliver

IPC: A61B3/11 ,  A61B3/14

CPC classification number: A61B3/112 ,  A61B5/16 ,  A61N1/36046 ,  A61N2005/0648

Abstract: A system for use during a medical procedure. The system includes a pupilometer for obtaining data descriptive of one or more pupilary characteristics from an eye of a subject, and means for delivering a noxious stimulus. The means for delivering a noxious stimulus is in communication with the pupilometer and is activated by the pupilometer thereby sending a noxious stimulus to an anatomical structure of the patient.

Abstract translation: 在医疗过程中使用的系统。 该系统包括用于从对象的眼睛获得描述一个或多个瞳孔特征的数据的瞳孔仪，以及用于递送有害刺激的装置。 用于传递有害刺激的手段与瞳孔仪通信，并由瞳孔仪激活，从而向患者的解剖结构发送有害的刺激。

公开(公告)号：US20060181678A1

公开(公告)日：2006-08-17

申请号：US11398049

申请日：2006-04-04

Applicant: Lawrence Stark ,  Claudio Privitera ,  Kamran Siminou ,  Jeffrey Oliver

Inventor： Lawrence Stark ,  Claudio Privitera ,  Kamran Siminou ,  Jeffrey Oliver

IPC: A61B3/14

CPC classification number: A61B3/112 ,  A61B5/16 ,  A61N1/36046 ,  A61N2005/0648

Abstract: A pupilometer having image capturing means, illumination means generating and emitting light of a first wavelength, stimulation means generating and emitting light of a second wavelength, and image processing software. The image processing software receives data from the image capturing means, identifies a pupil's dynamic response to light generated by the stimulation means, analyzes one or more components of the pupil's dynamic response, and produces an output comprising a value indicative of a neurological condition of a patient.

Abstract translation: 具有图像捕获装置的瞳孔仪，产生和发射第一波长的光的照明装置，产生和发射第二波长的光的刺激装置和图像处理软件。 图像处理软件从图像捕获装置接收数据，识别瞳孔对由刺激装置产生的光的动态响应，分析瞳孔的动态响应的一个或多个分量，并产生包括指示神经学状态的值的输出 患者。

公开(公告)号：US07753527B2

公开(公告)日：2010-07-13

申请号：US12367513

申请日：2009-02-07

Applicant: Kamran Siminou ,  Jeffrey Oliver

Inventor： Kamran Siminou ,  Jeffrey Oliver

IPC: A61B3/00 ,  G02B21/00

CPC classification number: A61B3/0083 ,  A61B3/10 ,  A61B3/185

Abstract: An ophthalmic examination system comprising a headrest with a detection element, and an ophthalmic instrument (OI) having a microprocessor and a sensor in communication with the microprocessor. The sensor is configured to detect the presence of the detection element, and the headrest is configured for coupling to the OI.

Abstract translation: 一种眼科检查系统，包括具有检测元件的头枕和具有微处理器和与微处理器通信的传感器的眼科仪器（OI）。 传感器被配置为检测检测元件的存在，头枕被配置为耦合到OI。

公开(公告)号：US20090174865A1

公开(公告)日：2009-07-09

申请号：US12210185

申请日：2008-09-13

Applicant: Claudio Privitera ,  Kamran Siminou

Inventor： Claudio Privitera ,  Kamran Siminou

IPC: A61B3/11

CPC classification number: A61B3/112 ,  A61B3/0025 ,  A61B3/0083 ,  A61B3/113 ,  A61B3/14 ,  A61B3/145 ,  A61B5/4011 ,  A61B5/7203 ,  A61B2560/0425

Abstract: A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source. The method further includes the steps of using a pupilometer to track the pupil's constriction response over a duration of time, wherein the step of tracking the pupil constriction response begins substantially simultaneously with or immediately subsequent to time 0 and lasts for a period of time y, and using the pupilometer to collect a plurality of data points in which each data point corresponds with a diameter of the pupil at a specific time within the time duration y. The method further includes the step of generating a pupil data profile by compiling the data points and determining whether one or more conditions arc met. wherein the one or more conditions comprises the following: (a) more than two data points exist representing the same pupil diameter at three or more separate times during duration y; (b) a first phase of the pupilary reflex response exists, wherein said first phase is characterized by a period of non-constriction immediately subsequent to time 0, said first phase having a duration of less than about 100 msec or greater than about 1000 msec; (c) if two data points exist representing the same pupil diameter at two separate times y1 and y2 during duration y, then the duration of time between y1 and y2 is less than about 100 msec: or during the first phase of the pupilary reflex, the diameter of the pupil increases before it decreases. Existence of one of said conditions indicates that the pupil reflex does not resemble a canonical reflex.

Abstract translation: 公开了一种筛选受试者的瞳孔以确定瞳孔反射是否类似于典型瞳孔反射的方法。 该方法包括用刺激源刺激瞳孔的步骤。 该方法还包括以下步骤：使用瞳孔仪在一段时间内跟踪瞳孔的收缩反应，其中跟踪瞳孔收缩反应的步骤基本上与时间0同时或紧随时刻0开始并持续一段时间y， 并且使用瞳孔仪来收集在该持续时间y内的特定时刻每个数据点与瞳孔的直径对应的多个数据点。 该方法还包括通过编译数据点并确定是否满足一个或多个条件来生成瞳孔数据简档的步骤。 其中所述一个或多个条件包括以下内容：（a）在持续时间y期间在三个或更多个分开的时间存在多于两个表示相同瞳孔直径的数据点; （b）存在瞳孔反射响应的第一阶段，其中所述第一阶段的特征在于在时间0之后的非收缩期，所述第一阶段具有小于约100毫秒或大于约1000毫秒的持续时间 ; （c）如果在持续时间y期间在两个分开的时间y1和y2处存在两个数据点，表示相同的瞳孔直径，则y1和y2之间的持续时间小于约100毫秒：或者在瞳孔反射的第一阶段期间， 瞳孔的直径在减小之前增加。 存在所述条件之一表明瞳孔反射不像典型的反射。

公开(公告)号：US6116736A

公开(公告)日：2000-09-12

申请号：US298670

申请日：1999-04-23

Applicant: Lawrence W. Stark ,  Claudio M. Privitera ,  Kamran Siminou ,  Jeffrey Oliver

Inventor： Lawrence W. Stark ,  Claudio M. Privitera ,  Kamran Siminou ,  Jeffrey Oliver

IPC: A61B3/11 ,  A61B10/00 ,  A61B3/14

CPC classification number: A61B3/112

Abstract: A pupilometer having a pupil irregularity or non-uniformity detection capability. The pupilometer may comprise an imaging sensor for generating signals representative of a pupil of an eye, a data processor; and a program executable by the data processor for enabling the data processor to process signals received from the imaging sensor and to thereby identify one or more regions of non-uniformity within an image of a perimeter of the pupil. The pupilometer may incorporate several innovative calibration and thresholding routines and may provide the basis for an innovative medical diagnostics system, when coupled to a network containing a suitable medical database and data processing hardware.

Abstract translation: 具有瞳孔不规则或不均匀性检测能力的瞳孔仪。 瞳孔仪可以包括用于产生表示眼睛瞳孔的信号的成像传感器，数据处理器; 以及可由数据处理器执行的程序，用于使数据处理器能够处理从成像传感器接收的信号，从而识别瞳孔周边图像内的一个或多个不均匀区域。 瞳孔仪可以包含几个创新的校准和阈值程序，并且当与包含合适的医学数据库和数据处理硬件的网络耦合时，可以为创新医学诊断系统提供基础。

公开(公告)号：US5831667A

公开(公告)日：1998-11-03

申请号：US723193

申请日：1996-09-27

Applicant: Kamran Siminou

Inventor： Kamran Siminou

IPC: G09B21/00 ,  H04N7/18

CPC classification number: G09B21/008 ,  H04N7/183

Abstract: A vision enhancement system and improved X-Y viewing table. The vision enhancement system employs an X-Y viewing table that provides a mount for a video headset, the video headset, a monitor, and an image processing system. The video headset includes a camera and a video display system and is configured to detachably engage the mount provided on the X-Y viewing table. The image processing system has at least one port for communicating with the camera and video display system of the headset and another port for communicating with the monitor. An X-Y table in accordance with the present invention may comprise a base, a sliding tray coupled to the base for supporting an item, such as a book or newspaper, having one or more lines of text formed thereon, and a headset mounting unit coupled to the base. The mounting unit is configured such that a video headset may be detachably mounted thereon, and such that the video headset is maintained in a fixed position and at a selected distance over the tray.

Abstract translation: 视力增强系统和改进的X-Y观察台。 视觉增强系统采用X-Y观察台，为视频耳机，视频耳机，显示器和图像处理系统提供了一个安装。 视频耳机包括相机和视频显示系统，并且被配置为可拆卸地接合设置在X-Y观看台上的支架。 图像处理系统具有至少一个用于与耳机的相机和视频显示系统通信的端口以及用于与监视器通信的另一个端口。 根据本发明的XY工作台可以包括底座，联接到基座的滑动托盘，用于支撑在其上形成有一行或多行文本的物品，例如书籍或报纸，以及耳机安装单元，其耦合到 的基地。 安装单元被配置为使得视频头戴式耳机可以可拆卸地安装在其上，并且使得视频耳机被保持在固定位置并且在托盘上选定的距离处。