专利检索 ap:("Katsutoshi Goto" OR "Masahiro Yamakage" OR "Tomoyasu Iwase" OR "Tokio Okano" OR "Yoshihiro Deguchi" OR "Masanobu Mizoguchi" OR "Atushi Takita" OR "Norihiro Fukuda") AND inv:"Katsutoshi Goto" 第 2 页

11.

发明授权
Vasoconstrictor peptide 失效
标题翻译：血管收缩肽

公开(公告)号：US4981950A

公开(公告)日：1991-01-01

申请号：US249429

申请日：1988-09-26

申请人： Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara

发明人： Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara

IPC分类号： A61K38/00 , C07K14/575

CPC分类号： C07K14/57536 , A61K38/00

摘要： Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond.In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium.The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.