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11.发明授权Application of highly conserved domain sequences from viral genome as template to design therapeutic slirnas 有权将来自病毒基因组的高度保守的结构域序列应用于模板，设计治疗性疾病公开(公告)号：US08217163B2
公开(公告)日：2012-07-10
申请号：US12886446
申请日：2010-09-20
申请人： York Yuan Yuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
发明人： York Yuan Yuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/13 , C12N2310/16 , Y02A50/465
摘要： This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
摘要翻译： 本发明涉及病毒基因组的高度保守序列的应用，特别是来自肠道病毒基因组的高度保守结构域作为模板来设计靶小配体RNA（sliRNA）。 所得的sliRNA是治疗由病理性血管发生引起的相关疾病的治疗活性成分。
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12.发明申请Application of Highly Conserved Domain Sequences From Viral Genome As Template To Design Therapeutic Slirnas 有权应用病毒基因组的高保守域序列作为设计治疗性Slirnas的模板公开(公告)号：US20120071542A1
公开(公告)日：2012-03-22
申请号：US12886446
申请日：2010-09-20
申请人： York YuanYuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
发明人： York YuanYuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
IPC分类号： A61K31/713 , A61P27/02 , A61P35/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/13 , C12N2310/16 , Y02A50/465
摘要： This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
摘要翻译： 本发明涉及病毒基因组的高度保守序列的应用，特别是来自肠道病毒基因组的高度保守结构域作为模板来设计靶小配体RNA（sliRNA）。 所得的sliRNA是治疗由病理性血管发生引起的相关疾病的治疗活性成分。
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13.发明授权Methods for introducing nucleic acids into mammalian cells using imidazolium lipids 有权使用咪唑类脂质将核酸引入哺乳动物细胞的方法公开(公告)号：US06245520B1
公开(公告)日：2001-06-12
申请号：US09626268
申请日：2000-07-25
申请人： Jinkang Wang , Ralph Niven , Yilin Zhang , Pingzhong Huang
发明人： Jinkang Wang , Ralph Niven , Yilin Zhang , Pingzhong Huang
IPC分类号： A61K314164
CPC分类号： C07D233/22 , C07D233/24
摘要： Methods for introducing nucleic acids into mammalian cells are provided which use imidazolium lipids. The imidazolium lipids have the formula: wherein R1 and R2 each independently represent a C8-C24 saturated or unsaturated hydrocarbon chain, uninterrupted or interrupted by from 1 to 3 heteroatom moieties selected from —O—, —S—, —NH— and —NR—; X represents —CH2—, —O—, —S—, —NH— or —NR—; wherein R is a lower alkyl group having from 1 to 4 carbon atoms; n is an integer of from 1 to 2; and A− is an anion.
摘要翻译： 提供了使用咪唑鎓脂质将核酸引入哺乳动物细胞的方法。 咪唑类脂质具有下式：其中R 1和R 2各自独立地代表C 8 -C 24饱和或不饱和的烃链，不间断或被1-3个选自-O - ， - S - ， - NH-和-NR - ; X表示-CH 2 - ， - O - ， - S - ， - NH-或-NR-; 其中R是具有1至4个碳原子的低级烷基; n为1〜2的整数， 而A-是阴离子。
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公开(公告)号：US06235310B1
公开(公告)日：2001-05-22
申请号：US09054769
申请日：1998-04-03
申请人： Jinkang Wang , Yi-Lin Zhang
发明人： Jinkang Wang , Yi-Lin Zhang
IPC分类号： A61K9127
CPC分类号： A61K9/1272
摘要： Methods and compositions are provided for the introduction of polyanionic molecules, in particular, nucleic acids, into mammalian cells using certain phosphatidyl ethanolamines as helper lipids in conjunction with various cationic lipids. In particular, cationic lipid-mediated transfection of mammalian cells is improved by the use of lipid carriers comprising DLPE or DiPPE and cationic lipids.
摘要翻译： 提供了使用某些磷脂酰乙醇胺作为辅助脂质与各种阳离子脂质结合使用聚阴离子分子，特别是核酸引入哺乳动物细胞的方法和组合物。 特别地，通过使用包含DLPE或DiPPE和阳离子脂质的脂质载体来改善哺乳动物细胞的阳离子脂质介导的转染。
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