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公开(公告)号：US07910111B2
公开(公告)日：2011-03-22
申请号：US10553686
申请日：2004-04-15
IPC分类号： A61K39/12
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/705 , C07K2319/10
摘要： Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptide to cross the cellular membrane (e.g. a domain from the TAT protein of HIV) and a domain that inhibits NSF (e.g. a domain of NSF). Administration of the fusion peptide promotes anticoagulation, attenuates thrombosis, and decreases heart attack severity.
摘要翻译： 提供了通过抑制调节胞吐作用的蛋白质阻断胞吐作用的方法和组合物，如N-乙基马来酰亚胺敏感因子（NSF）。 组合物包括含有导致融合肽跨越细胞膜的结构域的多结构域融合肽（例如来自HIV的TAT蛋白的结构域）和抑制NSF（例如NSF结构域）的结构域。 融合肽的施用促进抗凝，减轻血栓形成，降低心脏病发作严重性。
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公开(公告)号：US20050204075A1
公开(公告)日：2005-09-15
申请号：US11073719
申请日：2005-03-08
申请人： Kenji Matsushita
发明人： Kenji Matsushita
CPC分类号： G06F12/0215
摘要： A value of the number of prefetch words is preset by a master device 50 in a number of prefetch words setting section 14 of a slave device 10. The number of prefetch words refers to the number of data units sequentially receivable by the master device 50 at a time from the slave device 10. When the slave device 10 receives a read transfer request from the master device 50, a prefetch control section 13 reads from a memory 15 contiguous data units having a quantity equal to the value of the number of prefetch words, and then writes the contiguous data units into a data buffer 12. A bus interface 11 transmits the contiguous data units stored in the data buffer 12 to the master device 50.
摘要翻译： 预取字数的值由从设备10的预取字设置部分14中的主设备50预设。 预取字数是指从主设备50一次可从从设备10顺序接收的数据单元的数量。 当从设备10从主设备50接收到读传输请求时，预取控制部分13从存储器15读取具有等于预取字数的值的相邻数据单元，然后写入连续的数据单元 进入数据缓冲器12。 总线接口11将存储在数据缓冲器12中的连续数据单元发送到主设备50。
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