公开(公告)号：US20090274715A1

公开(公告)日：2009-11-05

申请号：US12342111

申请日：2008-12-23

申请人： Kozo Fujisaki ,  Hideyuki Nagasawa ,  Ikuo Igarashi ,  Hiroshi Suzuki ,  Chihiro Sugimoto ,  Gakunan Gen ,  Myonjo Yu ,  Naotoshi Tsuji

发明人： Kozo Fujisaki ,  Hideyuki Nagasawa ,  Ikuo Igarashi ,  Hiroshi Suzuki ,  Chihiro Sugimoto ,  Gakunan Gen ,  Myonjo Yu ,  Naotoshi Tsuji

IPC分类号： A61K39/00 ,  A61K38/46

CPC分类号： C07K16/40 ,  A61K38/00 ,  C12N9/2442 ,  C12Q1/34 ,  C12Y302/01014 ,  G01N2500/00

摘要： A novel chitinase, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the chitinase, and a screening method for screening a substance capable of modifying the chitinase, are disclosed. According to the chitinase, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as piroplasmosis, Q fever, or viral encephalitis.

摘要翻译： 公开了一种新颖的几丁质酶，编码该多核苷酸的多核苷酸，载体和包含多核苷酸的转化体，抗几丁质酶的抗体以及筛选能够修饰几丁质酶的物质的筛选方法。 根据几丁质酶，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染，例如弓形体病，Q发热或病毒性脑炎。

公开(公告)号：US06855319B1

公开(公告)日：2005-02-15

申请号：US09807459

申请日：1999-08-13

申请人： Hiromi Ikadai ,  Ikuo Igarashi ,  Naoyoshi Suzuki ,  Hideyuki Nagasawa ,  Kozo Fujisaki ,  Takeshi Mikami

发明人： Hiromi Ikadai ,  Ikuo Igarashi ,  Naoyoshi Suzuki ,  Hideyuki Nagasawa ,  Kozo Fujisaki ,  Takeshi Mikami

IPC分类号： C07H21/02 ,  C07H21/04 ,  C07K14/44 ,  C07K16/20 ,  C12N1/21 ,  C12N15/30 ,  G01N33/569 ,  A61K39/002 ,  A61K39/015 ,  C07K1/00

CPC分类号： G01N33/56905 ,  C07K14/44 ,  C07K16/20 ,  Y10S530/822

摘要： The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an .antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.

摘要翻译： 本发明提供了编码来自巴贝虫（Babesia caballi）的重组蛋白的巴贝虫（Babesia caballi）的裂殖子的蛋白质和能够特异性结合巴贝虫裂殖子的48kDa蛋白质的抗体的基因。 根据本发明，可以通过重组DNA技术稳定地制备巴贝氏菌的48kDa蛋白质和大量编码所述蛋白质的基因。 本发明还提供了一种用于诊断马贝氏病的方法，其包括通过使用本发明的重组蛋白作为抗原特异性检测存在于马血中的抗巴贝虫抗体，或通过使用马血检测胎儿巴马裂殖子的存在 本发明的抗体。