公开(公告)号：US20190309170A1

公开(公告)日：2019-10-10

申请号：US16309296

申请日：2017-06-21

Applicant: L'OREAL

Inventor： Stéphane SABELLE ,  Stéphane BLAIS ,  Aziz FADLI

IPC: C09B55/00 ,  A61Q5/10 ,  A61K8/49

Abstract: The subject of the present invention is symmetric or dissymetric azomethine direct dyes comprising at least one pyrazolopyridine unit of formula (I), a composition comprising said dyes, a process for treating keratin fibers using said dyes, a process for preparing these compounds, synthesis intermediates and a kit. In which formula (I) X, Y1, Y2, Z1, and R1 to R5 are as defined in the description.

公开(公告)号：US20160303018A1

公开(公告)日：2016-10-20

申请号：US15106083

申请日：2014-12-19

Applicant: L'OREAL

Inventor： Aziz FADLI ,  Stéphane BLAIS

IPC: A61K8/49 ,  A61Q5/06 ,  C07D471/04

CPC classification number: A61K8/494 ,  A61K2800/4324 ,  A61Q5/065 ,  A61Q5/10 ,  C07D471/04

Abstract: The invention relates to a 1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-amine compound of formula (I) below, addition salts thereof, optical isomers, geometrical isomers and tautomers thereof and/or solvates thereof: in which: .R2, R3, R4, R5, and R7 independently represent: a hydrogen or halogen atom; a C1-C4 alkyl radical; a C1-C4 hydroxyalkyl radical; a carboxyl radical; a (C1-C4)alkoxycarbonyl radical; .R1 and R6, which may be identical or different, represent: hydrogen atom; C1-C10 and preferably Ci-C6 alkyl radical, —optionally interrupted with one or more heteroatoms chosen from O and S or with one or more groups —NR and/or —optionally terminating with at least one group —NX1X2 or at least one group —OX3, .X1 and X2 independently denote—a hydrogen atom, a linear C1-C6 alkyl radical, a branched C3-C6 alkyl radical, a linear C1-C6 hydroxyalkyl radical or a branched C3-C6 hydroxyalkyl radical, X1 and X2 may form, with the nitrogen atom that bears them, a saturated or unsaturated 5- to 8-membered heterocycle, in which one of the ring members may be a heteroatom chosen from O, S and N; the said heterocycle possibly being substituted with one or more linear or branched C1-C4 alkyl or C1-C4 hydroxyalkyl radicals, .X3 denotes—a hydrogen atom—a linear C1-C4 or branched C3-C4 alkyl radical, and .R denotes—a hydrogen atom—a linear C1-C4 alkyl radical.

Abstract translation: 本发明涉及下式（I）的1,2,3,4-四氢吡啶并[2,3-b]吡嗪-7-胺化合物，其加成盐，旋光异构体，几何异构体和其互变异构体和/或溶剂合物 ：其中：R 2，R 3，R 4，R 5和R 7独立地表示：氢或卤素原子; C1-C4烷基; C1-C4羟基烷基; 羧基; （C1-C4）烷氧基羰基; •R 1和R 6可以相同或不同，表示：氢原子; C1-C10和优选C 1 -C 6烷基 - 任选被一个或多个选自O和S的杂原子或与一个或多个基团-NR和/或 - 任选地与至少一个基团-NX 1 X 2或至少一个基团 -O X 3，X 1和X 2独立地表示 - 氢原子，直链C 1 -C 6烷基，支链C 3 -C 6烷基，直链C 1 -C 6羟烷基或支链C 3 -C 6羟烷基，X 1和X 2可以 与带有它们的氮原子一起形成饱和或不饱和的5-至8-元杂环，其中一个环成员可以是选自O，S和N的杂原子; 所述杂环可能被一个或多个直链或支链C 1 -C 4烷基或C 1 -C 4羟基烷基取代，•X3表示 - 氢原子 - 直链C 1 -C 4或支链C 3 -C 4烷基，R表示 - 氢原子 - 直链C 1 -C 4烷基。