公开(公告)号：US10961242B2

公开(公告)日：2021-03-30

申请号：US16783893

申请日：2020-02-06

Applicant: LegoChem Biosciences, Inc.

Inventor： Dae Yon Lee ,  Sang Eun Chae ,  Eun Mi Jung ,  Eun Hye Yang ,  Yoon Jeong Choi ,  Chul-Woong Chung ,  Ju Hyun Shin ,  Yun Ki Kim ,  Hyun Jin Kwon ,  Jeong Hee Ryu ,  Eun Hye Ban ,  Yong Zu Kim ,  Yeong Soo Oh ,  Jeiwook Chae

IPC: C07D471/04 ,  C07D498/10 ,  C07D519/00 ,  C07D471/10 ,  C07D413/14 ,  C07D413/12 ,  C07D403/14 ,  C07D401/14 ,  C07D513/04

Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.

公开(公告)号：US20200069816A1

公开(公告)日：2020-03-05

申请号：US16545869

申请日：2019-08-20

Applicant: LegoChem Biosciences, Inc.

Inventor： Yong Zu Kim ,  Tae Kyo Park ,  Sung Ho Woo ,  Sun Young Kim ,  Jong Un Cho ,  Doo Hwan Jung ,  Ji Young Min ,  Hyang Sook Lee ,  Yun Hee Park ,  Jeong Hee Ryu ,  Kyu Man Oh ,  Yeong Soo Oh ,  Jeiwook Chae ,  Ho Young Song ,  Chul-Woong Chung ,  Jeon Yang

IPC: A61K47/68 ,  A61K47/69 ,  C07K16/32 ,  C07D249/04 ,  A61K47/54 ,  C07D519/00 ,  C07D487/04 ,  C07K19/00 ,  A61K47/50

Abstract: Provided herein are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.

公开(公告)号：US09993568B2

公开(公告)日：2018-06-12

申请号：US14898932

申请日：2015-05-27

Applicant: LegoChem Biosciences, Inc.

Inventor： Yong Zu Kim ,  Tae Kyo Park ,  Sung Ho Woo ,  Sun Young Kim ,  Jong Un Cho ,  Doo Hwan Jung ,  Ji Young Min ,  Hyang Sook Lee ,  Yun Hee Park ,  Jeong Hee Ryu ,  Kyu Man Oh ,  Yeong Soo Oh ,  Jeiwook Chae ,  Ho Young Song ,  Chul-Woong Chung ,  Jeon Yang

IPC: A61K39/00 ,  C07K16/32 ,  A61K47/48

CPC classification number: A61K47/6871 ,  A61K47/549 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6855 ,  A61K47/6889 ,  A61K47/69 ,  A61K2039/505 ,  C07D249/04 ,  C07D487/04 ,  C07D519/00 ,  C07K16/32 ,  C07K19/00 ,  C07K2317/24

Abstract: Provided are methods of use of compounds comprising a self-immolative group, which compounds may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.

公开(公告)号：US10183997B2

公开(公告)日：2019-01-22

申请号：US15276209

申请日：2016-09-26

Applicant: LegoChem Biosciences, Inc.

Inventor： Yong Zu Kim ,  Yun Hee Park ,  Jeong Hee Ryu ,  Ho Young Song ,  Jeiwook Chae ,  Chul-Woong Chung ,  Ji Eun Jung ,  Hyo Jung Choi

IPC: C07D301/10 ,  C07K16/28 ,  A61K47/68 ,  A61K31/351

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-CD19 antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

公开(公告)号：US10118965B2

公开(公告)日：2018-11-06

申请号：US15276231

申请日：2016-09-26

Applicant: LegoChem Biosciences, Inc.

Inventor： Yong Zu Kim ,  Yun Hee Park ,  Hyo Jung Choi ,  Ji Eun Jung ,  Jeong Hee Ryu ,  Ho Young Song ,  Jeiwook Chae ,  Chul-Woong Chung

IPC: C07K16/28 ,  A61K47/68

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-epidermal growth factor receptor (“EGFR”) antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the drug; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

公开(公告)号：US20170088621A1

公开(公告)日：2017-03-30

申请号：US15276231

申请日：2016-09-26

Applicant: LegoChem Biosciences, Inc.

Inventor： Yong Zu Kim ,  Yun Hee Park ,  Hyo Jung Choi ,  Ji Eun Jung ,  Jeong Hee Ryu ,  Ho Young Song ,  Jeiwook Chae ,  Chul-Woong Chung

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6889

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-epidermal growth factor receptor (“EGFR”) antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the drug; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.